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首页> 外文期刊>The Journal of Antimicrobial Chemotherapy >Activity of ketolide ABT-773 (cethromycin) against erythromycin-resistant Streptococcus pneumoniae: correlation with extended MLSK phenotypes.
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Activity of ketolide ABT-773 (cethromycin) against erythromycin-resistant Streptococcus pneumoniae: correlation with extended MLSK phenotypes.

机译：酮内酯ABT-773（红霉素）对耐红霉素的肺炎链球菌的活性：与扩展的MLSK表型相关。

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摘要

OBJECTIVES: (i) To determine the inhibitory and bactericidal activities of ABT-773, a novel ketolide, against sensitive and erythromycin-resistant pneumococci; (ii) to subdivide erythromycin-resistant pneumococci into resistance phenotypes, more extensive than the conventional M and MLS(B) groups, by assessing susceptibilities to, and interactions between, erythromycin (14-membered macrolide), clindamycin (lincosamide), rokitamycin (16-membered macrolide), ABT-773 (ketolide), quinupristin (streptogramin B) and dalfopristin (streptogramin A). METHODS: MICs and MBCs of ABT-773 were determined for 165 strains of pneumococci (113 resistant to erythromycin). Extended phenotypes for the erythromycin-resistant strains were described in terms of intrinsic susceptibility to, and induction of resistance by, the antibiotics listed above. RESULTS: Erythromycin-resistant strains could be divided into 10 extended phenotypes (designated II-XI), two of which (II and IX) predominated. ABT-773 at 0.12 mg/L inhibited 109 strains (median 0.03 mg/L). MICs for the other four strains (of phenotypes X and XI) were 0.25-1 mg/L. MICs were only slighter higher when measured on agar in CO(2) than by the NCCLS method (in broth in air). MBCs were usually 1 mg/L, and three of the latter (all type X) were tolerant. Clones of reduced susceptibility (MICs 1-8 mg/L, increased by up to 32-fold) could be isolated from some strains of phenotypes VII, IX and X, but not from those of type II (efflux mechanism) or from erythromycin-sensitive strains. CONCLUSIONS: ABT-773 was active against all 113 erythromycin-resistant pneumococci tested, which belonged to 10 phenotypes. Extended phenotyping of pneumococci revealed interesting and potentially useful subdivisions of the classical phenotypes.
机译：目的：（i）确定一种新型的酮内酯ABT-773对敏感和耐红霉素的肺炎球菌的抑制和杀菌活性; （ii）通过评估对红霉素（14元大环内酯），克林霉素（林可酰胺），罗奇霉素（ 16元大环内酯），ABT-773（酮内酯），奎奴普丁（链霉菌素B）和达福普汀（链霉菌素A）。方法：测定了165株肺炎球菌（113株对红霉素耐药）的ABT-773的MIC和MBC。关于红霉素抗性菌株的扩展表型以对上述抗生素的内在敏感性和诱导抗性来描述。结果：红霉素耐药菌株可分为10个扩展表型（命名为II-XI），其中两个（II和IX）占主导。 0.12 mg / L的ABT-773抑制109株（中值0.03 mg / L）。其他四个菌株（表型X和XI）的MIC为0.25-1 mg / L。当在琼脂中用CO（2）进行测定时，MIC仅比通过NCCLS方法（在空气中的肉汤中）高。 MBC通常为 1 mg / L，后者中的三个（均为X型）是耐受的。可以从某些表型VII，IX和X的菌株中分离出敏感性降低的克隆（MICs 1-8 mg / L，增加多达32倍），而不能从II型（外排机制）或红霉素分离出。敏感菌株。结论：ABT-773对所有经测试的113株抗红霉素的肺炎球菌均具有活性，属于10个表型。肺炎球菌的扩展表型揭示了经典表型的有趣和潜在有用的细分。

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