REDUCTION OF CAMPHTHOTECINE BY 1,4-DIHYDROPYRIDINE

A. N. Ivchenko; A. N. Balaev; E. A. Ruchko; V. E. Fedorov

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REDUCTION OF CAMPHTHOTECINE BY 1,4-DIHYDROPYRIDINE

机译：1,4-二氢吡啶还原甘氨酸

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Topotecan (1) is an antitumor drug, whose cytotoxic action is related to the inhibition of DNA topoisomerase I. The key step in the synthesis of topotecan (1) is the reduction of camphthotecine (2) to give 1,2,6,7-tetrahydrocamphthotecine (3) [1]. Published variants of this reduction involve the hydrogenation of compound 2 on either platinum or palladium catalysts at atmospheric or elevated pressure [2].

机译：拓扑替康（1）是一种抗肿瘤药，其细胞毒性作用与DNA拓扑异构酶I的抑制有关。拓扑替康（1）合成的关键步骤是还原樟脑素（2）以得到1,2,6,7 -四氢樟脑素（3）[1]。这种还原的已公开变体涉及在大气压或高压下在铂或钯催化剂上氢化化合物2 [2]。

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来源
《Chemistry of heterocyclic compounds》 |2014年第2期|共2页
作者
A. N. Ivchenko; A. N. Balaev; E. A. Ruchko; V. E. Fedorov;
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正文语种 eng
中图分类杂环化合物;
关键词
camphthotecine; 1; 4-dihydropyridine; topotecan; reduction.;

机译：樟脑茶碱;1;4-二氢吡啶;拓扑替康;还原;

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1. REDUCTION OF CAMPHTHOTECINE BY 1,4-DIHYDROPYRIDINE [J] . A. N. Ivchenko, A. N. Balaev, E. A. Ruchko, Chemistry of heterocyclic compounds . 2014,第2期

机译：1,4-二氢吡啶还原甘氨酸
2. 1,4-Dihydropyridine/BF3OEt2 for the reduction of imines: Influences of the amount of added BF3OEt2 and the substitution at N-1 and C-4 of the dihydropyridine ring [J] . Zattoni Ingrid F., Guanaes Lais D., Cerqueira Leticia B., Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2019,第40期

机译：1,4-二氢吡啶/ BF3OET2用于减少亚胺：加入的BF3OET2的量和二氢吡啶环的N-1和C-4的取代的影响
3. Selective Reduction of Nitroarenes by a Hantzsch 1,4-Dihydropyridine: A Facile and Efficient Approach to Substituted Quinolines [J] . Rui Guang Xing, Ya Nan Li, Qiang Liu, Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2011,第13期

机译：汉茨1,4-二氢吡啶对硝基芳烃的选择性还原：一种替代喹啉的简便有效方法
4. Highly Efficient Synthesis of 1,4-Dihydropyridine DerivativesUsing DBU [C] . Kazuya Nakajima, Masashi Kajitani, Takeshi Oriyama 日本化学会春季年会 . 2020

机译：高效合成1,4-二氢吡啶衍生物DBU
5. Investigating The Anti-Cancer Properties of Novel Hybrid 1,4-Dihydropyridine Derivatives in U-87mg Glioblastoma Cell Line [D] . Hunyenyiwa, Tendai 2019

机译：在U-87mg胶质母细胞瘤细胞系中研究新型杂种1,4-二氢吡啶衍生物的抗癌特性
6. Molecular simulations study of novel 1,4-dihydropyridines derivatives with a high selectivity for Cav3.1 calcium channel [O] . Xiaoguang Liu, Hui Yu, Xi Zhao, 2012

机译：对Cav3.1钙通道具有高选择性的新型1,4-二氢吡啶衍生物的分子模拟研究
7. Stereoselective reduction of benzoin by the NADH model 3-(dimethylcarbamoyl)-1,2,4-trimethyl-1,4-dihydropyridine [O] . Beijer, NA Nicoline, Vekemans, JAJM Jef = Jozef, Buck, HM Henk 2010

机译：NADH模型3-（二甲基氨基甲酰基）-1,2,4-三甲基-1,4-二氢吡啶的立体选择性还原安息香

REDUCTION OF CAMPHTHOTECINE BY 1,4-DIHYDROPYRIDINE

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