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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Evaluation of renal function in transplant patients on tacrolimus therapy.
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Evaluation of renal function in transplant patients on tacrolimus therapy.

机译：他克莫司治疗对移植患者肾功能的评估。

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摘要

Glomerular filtration rate (GFR), as measured by 24-hour creatinine clearance and clearance of iothalamate, and effective renal plasma flow (ERPF), as measured by the clearance of para-aminohippuric acid (PAH), were evaluated at 2 weeks, 1 month, and 3 months after transplantation in 8 renal transplant patients and at 1 month and 1 year after transplantation in 9 liver transplant patients receiving tacrolimus (Prograf) therapy. In renal transplant patients, there was a significant increase in GFR after transplantation. There was no change in GFR at 1 and 3 months as compared to 2 weeks after transplantation, while ERPF (ml/min/1.73 m2) was lower (p < 0.05) at 3 months (212+/-42) compared to 1 month (306+/-118) after transplantation. In liver transplant patients, GFR and ERPF were below normal despite normal serum creatinine concentrations, but there was no difference in GFR or ERPF at 1 month and 1 year after transplantation. Although below normal, renal function was well preserved in transplant patients while receiving chronic tacrolimus therapy over the study period. Dosage alterations ofrenally eliminated drugs may be required for drugs with a narrow therapeutic index.
机译：在第2周时评估了肾小球滤过率（GFR）（通过24小时肌酐清除率和碘乙酸酯的清除率测量）和有效肾血浆流量（ERPF）（通过对氨基马尿酸（PAH）的清除率测量），1 8例肾移植患者在移植后1个月和3个月以及9例接受他克莫司（Prograf）治疗的肝移植患者在移植后1个月和1年。在肾移植患者中，移植后GFR显着增加。与移植后2周相比，在1和3个月时GFR没有变化，而在3个月（212 +/- 42）时，ERPF（ml / min / 1.73 m2）则比1个月低（p <0.05） （306 +/- 118）。在肝移植患者中，尽管血清肌酐水平正常，GFR和ERPF仍低于正常水平，但在移植后1个月和1年时，GFR或ERPF没有差异。尽管低于正常水平，但在研究期内接受慢性他克莫司治疗的移植患者的肾功能仍得到很好的保存。对于治疗指数较窄的药物，可能需要改变肾脏清除药物的剂量。

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