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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Transcutaneous electrical acupoint stimulation potentiates analgesic effect of morphine.
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Transcutaneous electrical acupoint stimulation potentiates analgesic effect of morphine.

机译：经皮穴位电刺激可增强吗啡的镇痛作用。

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摘要

Pain is the major complaint of patients who choose acupuncture treatment. Transcutaneous electrical acupoint stimulation (TEAS) provides a safe, standardized technique without needle insertion. TEAS can be tested with the cold-pressor test, a simple, reliable, and widely used model in humansfor the induction of tonic pain. In this controlled study, the effects of TEAS on cold-pressor-induced pain were evaluated in 20 healthy human subjects. Electrical stimulation electrodes were applied to He-Gu (LI 4) and Nui-Guan (P 6) acupoints. The effects of saline plus no TEAS, 15-minute TEAS alone, 0.05 mg/kg morphine alone, and 15-minute TEAS plus morphine were assessed. Pain score ratings were evaluated at four time points from 30 to 170 seconds during the cold-pressor test. The authors observed analgesic effects in both TEAS-alone and morphine-alone sessions, and pain score rating reductions were statistically significant compared to unstimulated control (both p < 0.01). The degree of TEAS analgesia combined with 0.05 mg/kg morphine was significantly higher than TEAS alone (p < 0.01). The results support the efficacy of TEAS analgesia and suggest that combination of TEAS with low-dose morphine can achieve better pain control in a variety of clinical settings.
机译：疼痛是选择针灸治疗的患者的主要主诉。经皮穴位电刺激（TEAS）提供了一种安全，标准化的技术，无需插入针头。 TEAS可以通过冷压试验进行测试，冷压试验是一种简单，可靠且在人体中广泛使用的诱发强直性疼痛的模型。在这项对照研究中，评估了20名健康人类受试者中TEAS对冷压诱发疼痛的影响。将电刺激电极应用于合谷穴（LI 4）和Nui-Guan（P 6）穴位。评估了盐水加无TEAS，单独15分钟TEAS，单独0.05 mg / kg吗啡和15分钟TEAS加吗啡的效果。在冷压测试期间的30到170秒的四个时间点评估疼痛评分等级。作者在单独的TEAS和单独的吗啡疗程中均观察到了镇痛作用，与未刺激的对照组相比，疼痛评分降低的幅度具有统计学意义（均p <0.01）。 TEAS镇痛与0.05 mg / kg吗啡合用的程度显着高于单独的TEAS（p <0.01）。结果支持TEAS镇痛的效果，并表明TEAS与低剂量吗啡的组合可以在各种临床环境中实现更好的疼痛控制。

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