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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Plasma nitric oxide before and after smoking cessation with nicotine nasal spray.
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Plasma nitric oxide before and after smoking cessation with nicotine nasal spray.

机译：尼古丁鼻喷雾剂戒烟前后的血浆一氧化氮。

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摘要

Nicotine may affect cardiovascular function through release of neurotransmitters from autonomic nerves or release of vasoactive substances from the vascular endothelium. Nitric oxide is a neurotransmitter and endothelium-derived factor that reduces tone of vascular smooth muscle. Experiments were designed to determine whether or not use of nicotine nasal spray for smoking cessation affects plasma levels of nitric oxide. Forty smokers self-administered nicotine by nasal spray (one 0.5 mg spray to each nostril). Blood samples were taken before the use of the nasal spray and at treatment day 7 for the measurement of cotinine by high pressure liquid chromatography and nitric oxide (NOx) by chemiluminescence. Age-comparable controls were never-smokers nonnicotine users recruited from laboratory personnel. Mean plasma concentrations of NOx from smokers before treatment were significantly greater compared with nonsmokers (23 +/- 10, n = 40 and 15 +/- 6, n = 13 nmoles/mL [mean +/- SD], respectively, P < 0.01). Plasma NOx in smokers was not significantly correlated with the average daily number of cigarettes smoked (r2 = 0.02, P > 0.05) but was positively and linearly correlated with plasma cotinine (r2 = 0.13, P < 0.02). In 32 self-reported abstinent smokers (confirmed by expired carbon monoxide < 9 ppm) using nicotine nasal spray, cotinine decreased by 64% from pretreatment levels of 284 +/- 103 to posttreatment levels of 90 +/- 58 ng/mL. Plasma NOx was unchanged and went from 23.0 +/- 10.1 at pretreatment to 21 +/- 12 nmoles/mL with nicotine treatment. These results suggest that nicotine-use, independent of cigarette smoking, affects plasma NOx.
机译：尼古丁可能通过从自主神经释放神经递质或从血管内皮释放血管活性物质来影响心血管功能。一氧化氮是一种神经递质和内皮源性因子，可降低血管平滑肌的语气。设计实验来确定使用尼古丁鼻喷雾剂戒烟是否会影响一氧化氮的血浆水平。四十名吸烟者通过鼻喷雾剂自用尼古丁（每个鼻孔喷一次0.5 mg）。在使用鼻喷雾剂之前以及在治疗的第7天采集血液样本，以通过高压液相色谱法测定可替宁，并通过化学发光法测定一氧化氮（NOx）。年龄可比的对照组是从实验室人员招募的永不吸烟的非尼古丁使用者。与非吸烟者相比，治疗前吸烟者的平均NOx血浆浓度显着更高（分别为23 +/- 10，n = 40和15 +/- 6，n = 13 nmoles / mL [平均值+/- SD]，P < 0.01）。吸烟者血浆NOx与平均每天吸烟量之间无显着相关性（r2 = 0.02，P> 0.05），但与血浆可替宁呈线性正相关（r2 = 0.13，P <0.02）。在使用尼古丁鼻喷雾剂的32名自我报告的戒烟者中（通过过期的一氧化碳<9 ppm确认），可替宁从治疗前的水平284 +/- 103降至治疗后的90 +/- 58 ng / mL，降低了64％。血浆NOx保持不变，并从尼古丁治疗前的23.0 +/- 10.1升至治疗前的21 +/- 12 nmoles / mL。这些结果表明，与吸烟无关，尼古丁的使用会影响血浆NOx。

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