Drug-binding cavities in long-lived biologics: cause for concern but also potential benefit.

Panayotatos N

首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Drug-binding cavities in long-lived biologics: cause for concern but also potential benefit.

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Drug-binding cavities in long-lived biologics: cause for concern but also potential benefit.

机译：长寿生物制剂中的药物结合腔：令人关注，但也有潜在好处。

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Universally present but overlooked cavities or pockets in long-lived biopharmaceuticals, such as monoclonal antibodies (mAbs), are capable of binding small drugs. Such direct interactions can alter the pharmacokinetics of drugs and potentially affect clinical outcome. The extreme differences in the pharmacokinetic properties of these 2 classes of drugs largely account for such effects. This overlooked mechanism of biologic-chemical drug interaction should be considered before approval of new long-lived entities.

机译：寿命长的生物药品（例如单克隆抗体（mAb））中普遍存在但被忽略的空腔或口袋能够结合小型药物。这种直接相互作用可以改变药物的药代动力学，并可能影响临床结果。这两种药物在药代动力学特性上的极端差异在很大程度上解释了这种效应。在批准新的长期存在的实体之前，应考虑这种被忽略的生化药物相互作用机制。

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《The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology》 |2008年第10期|共4页
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Panayotatos N;
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正文语种 eng
中图分类药理学;
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机译：长寿生物制剂中的药物结合腔：令人关注，但也有潜在好处。
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Drug-binding cavities in long-lived biologics: cause for concern but also potential benefit.

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