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首页> 外文期刊>The journal of clinical psychiatry >Normal P50 gating in children with autism.
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Normal P50 gating in children with autism.

机译：自闭症儿童的正常P50门控。

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BACKGROUND: An important characteristic of children with autism is their unusual reaction to stimuli, which may be related to problems in the filtering of sensory input. For this reason, sensory filtering was measured in children with autism using the P50 gating paradigm. METHOD: Twelve non-mentally retarded children with autism (i.e., having a DSM-IV diagnosis of either autistic disorder or pervasive developmental disorder not otherwise specified) and 11 healthy control children were tested for their ability to suppress P50, measured at the Cz electrode. RESULTS: No differences were found between the children with autism and the control children with regard to absolute P50 amplitudes and P50 suppression. CONCLUSION: The excitability of the neuronal substrate that causes P50 is normal in children with autism, as are the early, inhibitory processes related to P50 gating. These results distinguish between subjects with autism and subjects with schizophrenia, in whom sensory gating is abnormal.
机译：背景：自闭症儿童的一个重要特征是他们对刺激的异常反应，这可能与感觉输入过滤方面的问题有关。因此，使用P50门控范例对自闭症儿童进行了感觉过滤。方法：对12名非智障自闭症儿童（即，未另行指定自闭症或普遍性发育障碍的DSM-IV诊断）和11名健康对照儿童在Cz电极上测定其抑制P50的能力。结果：自闭症患儿和对照组患儿在绝对P50振幅和P50抑制方面没有发现差异。结论：自闭症儿童的神经元底物引起P50的兴奋性是正常的，与P50门控相关的早期抑制过程也是如此。这些结果区分了感觉门控异常的自闭症患者和精神分裂症患者。

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