...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Defining Response in Clinical Trials for Obsessive-Compulsive Disorder: A Signal Detection Analysis of the Yale-Brown Obsessive Compulsive Scale.
【24h】

Defining Response in Clinical Trials for Obsessive-Compulsive Disorder: A Signal Detection Analysis of the Yale-Brown Obsessive Compulsive Scale.

机译：定义强迫症的临床试验中的反应：耶鲁-布朗强迫症量表的信号检测分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Many studies of the treatment of obsessive-compulsive disorder (OCD) have used percent reduction cutoffs on the Yale-Brown Obsessive Compulsive Scale (YBOCS) to classify patients as treatment responders. However, reduction criteria have varied from 20% to 50%, with studies of cognitive-behavioral therapy (CBT) using a more stringent criterion than studies of pharmacotherapy. The aim of this retrospective investigation was to determine optimal YBOCS reduction criteria for classifying patients as responders. METHOD: Data from 87 adult clinic and research outpatients meeting DSM-IV-TR criteria for OCD according to structured interview were examined, comparing the percent YBOCS reduction from pretreatment to posttreatment with 2 "gold standard" criteria from the Clinical Global Impressions (CGI) scale: much or very much improved and mild illness or better. Signal detection analyses were used to determine the sensitivity, specificity, predictive value of a positive test, predictive value of a negative test, and efficiency of various YBOCS reduction cutoffs. RESULTS: A YBOCS reduction cutoff of 30% was optimal for predicting improvement on the CGI. The 20% cutoff used by many pharmacologic studies resulted in a high number of false positives, whereas the 50% cutoff used by most CBT studies resulted in a high number of false negatives. For predicting mild illness or better at posttreatment, a YBOCS reduction cutoff of 40% to 50% was optimal. CONCLUSIONS: A YBOCS reduction criterion of 30% appears to be optimal for determining clinical improvement, whereas a 40% to 50% reduction criterion is appropriate for predicting mild illness at posttreatment. Future studies should employ a standard definition of treatment response in order to facilitate cross-study comparisons.
机译：目的：许多关于强迫症治疗的研究都采用耶鲁-布朗强迫症量表（YBOCS）的降低百分比临界值将患者归类为治疗反应者。但是，降低标准从20％到50％不等，认知行为疗法（CBT）的研究标准比药物疗法更严格。这项回顾性研究的目的是确定将患者分类为反应者的最佳YBOCS降低标准。方法：根据结构化访谈，对来自87位满足强迫症的DSM-IV-TR标准的成人门诊和研究门诊患者的数据进行了检查，比较了临床前总印象数（CGI）中2种“金标准”标准从治疗前到治疗后YBOCS减少的百分比规模：改善很多或非常多，轻度疾病或好转。信号检测分析用于确定敏感性，特异性，阳性试验的预测值，阴性试验的预测值以及各种YBOCS降低临界值的效率。结果：YBOCS降低阈值30％是预测CGI改善的最佳选择。许多药理研究使用的20％临界值导致大量假阳性，而大多数CBT研究使用的50％临界值导致大量假阴性。为了预测轻度疾病或在治疗后更好，将YBOCS降低的临界值设定为40％至50％是最佳的。结论：YBOCS降低标准为30％似乎是确定临床改善的最佳选择，而40％至50％的降低标准则适合预测治疗后的轻度疾病。未来的研究应采用治疗反应的标准定义，以促进交叉研究的比较。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号