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首页> 外文期刊>The journal of clinical psychiatry >Dual reuptake inhibitors incur lower rates of tachyphylaxis than selective serotonin reuptake inhibitors: a retrospective study.
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Dual reuptake inhibitors incur lower rates of tachyphylaxis than selective serotonin reuptake inhibitors: a retrospective study.

机译：一项回顾性研究显示，与选择性5-羟色胺再摄取抑制剂相比，双重再摄取抑制剂的速激肽发生率更低。

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BACKGROUND: The notion that selective serotonin reuptake inhibitors (SSRIs) may be associated with higher relapse rates than other antidepressants during maintenance treatment (tachyphylaxis) has been discussed for years, but to date there is little or no empirical evidence confirming this phenomenon. In this study, we systematically assessed prior anti-depressant treatment history in a cohort of depressed patients who presented for outpatient psychiatric treatment. Rates of tachyphylaxis were compared in venlafaxine and tricyclic antidepressants (TCAs), which act as dual reuptake inhibitors, versus SSRIs. METHOD: 237 patients who presented for treatment at the Rhode Island Hospital Department of Psychiatry's outpatient practice and were diagnosed with DSM-IV major depressive disorder were interviewed with the semistructured Treatment Response to Antidepressant Questionnaire. This cohort reported having undergone 326 prior SSRI trials, 47 prior venlafaxine trials, and 35 prior trials with a TCA. Rates of tachyphylaxis as a function of antidepressant class were compared. RESULTS: Rates of tachyphylaxis were significantly lower (chi(2) = 6.77, df = 1, p = .01) with the dual reuptake inhibitors venlafaxine and TCAs (3 [3.7%] of 82) compared to rates of tachyphylaxis with SSRIs (46 [14.1%] of 326). CONCLUSION: These results provide preliminary evidence that dual reuptake inhibitors may incur lower rates of tachyphylaxis than SSRIs. By virtue of the retrospective and non-random design of the study, these results warrant confirmation.
机译：背景：关于5-羟色胺再摄取抑制剂（SSRIs）在维持治疗（速激肽疗法）中可能比其他抗抑郁药复发率更高的观点有关，但迄今为止，几乎没有或没有经验证据证实这种现象。在这项研究中，我们系统地评估了一组接受门诊精神病治疗的抑郁患者的先前抗抑郁治疗史。比较了文拉法辛和三环类抗抑郁药（TCA）与SSRI相比的速激肽发生率。方法：对在罗德岛医院精神病科门诊就诊并确诊为DSM-IV重度抑郁症的237例患者进行了抗抑郁问卷半结构化治疗访谈。该队列报道已接受326次SSRI先前试验，47项文拉法辛先前试验和35例TCA先前试验。比较了速激肽作为抗抑郁药类别的函数。结果：与SSRIs速激肽相比，双重再摄取抑制剂文拉法辛和TCA的速激肽发生率显着降低（chi（2）= 6.77，df = 1，p = .01）（占82的3 [3.7％]）。 326中的46 [14.1％]。结论：这些结果提供了初步的证据，表明双重再摄取抑制剂可能比速激肽释放激素引起的速激肽发生率更低。根据研究的回顾性和非随机性设计，这些结果值得确认。

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