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首页> 外文期刊>The journal of clinical psychiatry >Behavioral therapy for weight loss in patients with schizophrenia.
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Behavioral therapy for weight loss in patients with schizophrenia.

机译：精神分裂症患者体重减轻的行为疗法。

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Compared with the general population, individuals with schizophrenia demonstrate an increased prevalence of obesity. While most antipsychotics are associated with weight gain, certain second-generation antipsychotics (SGAs) appear to be especially problematic. Weight gain and obesity are highly distressing to these patients, can reduce treatment adherence, and may increase the relative risk of serious medical conditions and all-cause premature mortality. The selection of an antipsychotic on the basis of its effectiveness and relative side effect profile is recognized as an important initial consideration in the treatment of schizophrenia. However, less is known regarding the efficacy of dietary, pharmacologic, and behavioral therapy in reducing antipsychotic-related weight gain and obesity. Behavioral therapy, in particular, is understudied, and there are relatively few controlled trials of its effectiveness in reducing SGA-induced weight gain. Although weight loss resulting from behavioral therapy hasbeen observed mostly as a result of effective short-term interventions, controlled behavioral studies do exist to suggest that weight can be controlled long term. In addition, a small pilot study in patients with schizophrenia or schizoaffective disorder recently demonstrated that behavioral therapy that utilizes stepped interventions, involving body weight self-monitoring, diet, and exercise, can prevent weight gain in patients initiating treatment with SGAs. Additional studies of behavioral therapy for long-term weight control in patients with schizophrenia and other forms of severe mental illness are warranted.
机译：与普通人群相比，精神分裂症患者的肥胖发生率增加。虽然大多数抗精神病药与体重增加有关，但某些第二代抗精神病药（SGA）似乎特别有问题。体重增加和肥胖症对这些患者极度困扰，可降低治疗依从性，并可能增加严重疾病和全因过早死亡的相对风险。基于抗精神病药的有效性和相对的副作用，选择抗精神病药被认为是治疗精神分裂症的重要初始考虑因素。但是，关于饮食，药物和行为疗法在减少抗精神病药物引起的体重增加和肥胖方面的功效知之甚少。特别是对行为疗法的研究还不够，关于减少SGA引起的体重增加的有效性的对照试验相对较少。尽管行为疗法导致的体重减轻主要是由于有效的短期干预而引起的，但确实存在受控的行为研究表明体重可以长期控制。此外，最近对精神分裂症或精神分裂症患者进行的一项小型先导研究表明，采用逐步干预的行为疗法，包括体重自我监测，饮食和运动，可以防止开始使用SGA治疗的患者体重增加。有必要对精神分裂症和其他形式的严重精神疾病患者进行长期体重控制行为疗法的研究。

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