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首页> 外文期刊>The journal of clinical psychiatry >Prevalence of Negative Symptoms in Outpatients With Schizophrenia Spectrum Disorders Treated With Antipsychotics in Routine Clinical Practice: Findings From the CLAMORS Study
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Prevalence of Negative Symptoms in Outpatients With Schizophrenia Spectrum Disorders Treated With Antipsychotics in Routine Clinical Practice: Findings From the CLAMORS Study

机译：在常规临床实践中，用抗精神病药治疗的精神分裂症谱系疾病门诊患者的阴性症状患病率：CLAMORS研究结果

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Objective: To analyze the prevalence of negative symptoms in antipsychotic-treated outpatients with schizophrenia spectrum disorders.Method: A cross-sectional, retrospective multicenter study was carried out between May 2004 and April 2005 in 1,704 adult psychiatric outpatients meeting DSM-IV criteria for schizophrenia, schizophreniform, or schizo-affective disorder. We used 5 items of the Positive and Negative Syndrome Scale (PANSS) negative symptoms subscale to individually determine the presence of a negative symptom when the score on the item was > 3. Primary negative symptoms were considered present when patients fulfilled all of the following: > 3 score on the corresponding item; < 3 score on any positive item; no extrapyramidal symptoms; < 3 score on anxiety and depression items; dose of haloperidol, when applicable, < 15 mg/d; and no antiparkinsonian treatment.Results: A total of 1,452 evaluable patients (863 men, 60.9%), 40.7 ? 12.2 (mean?D) years of age, were included. One or more negative symptoms were present in 57.6% of patients, with primary negative symptoms in 12.9% of subjects. The most frequent negative symptom items were social withdrawal (45.8%), emotional withdrawal (39.1%), poor rapport (35.8%), and blunted affect (33.1%). Negative symptoms (1-blunted affect, 2-emotional withdrawal, 3-poor rapport, 4-social withdrawal, 5-verbal fluency) were most associated with maleness (symptom 4); age > 40/45 years (men/women; symptoms 1,2,4); single/unmarried status (symptoms 2-4); unemployment (symptoms 3,4); higher score on the Clinical Global Impressions (CGI) scale and PANSS total score (symptoms 1-5); lower score on the PANSS positive symptoms subscale (symptoms 1,3); more than 52 weeks of treatment (symptoms 1-3,5); and high antipsychotic dose (symptom 2).Conclusions: The prevalence of negative symptoms in patients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice not only is still considerably high but also seems to be related to poorer functioning, unemployment, greater severity, and less positive symptomatology and higher antipsychotic dose.
机译：目的：分析抗精神病药物治疗精神分裂症患者的阴性症状患病率。方法：于2004年5月至2005年4月，对符合DSM-IV精神分裂症标准的1,704名成人精神病患者进行横断面回顾性多中心研究。 ，精神分裂症或精神分裂症。我们使用5个项目的阳性和阴性综合症状量表（PANSS）阴性症状分量表来单独确定当该项目的得分> 3时是否存在阴性症状。当患者满足以下所有条件时，就认为存在主要阴性症状：对应项目> 3分;在任何积极项目中得分<3;没有锥体束外症状; <焦虑和抑郁项目得分<3;氟哌啶醇的剂量（如适用）<15 mg / d;结果：共有1452名可评估患者（863名男性，占60.9％），占40.7？年龄为12.2岁（平均）。 57.6％的患者存在一种或多种阴性症状，其中12.9％的患者具有原发性阴性症状。最常见的负面症状项目是社交退缩（45.8％），情绪退缩（39.1％），融洽的关系（35.8％）和情感迟钝（33.1％）。阴性症状（1-钝化情绪，2-情绪退缩，3-差融洽，4-社交退缩，5-口头流利）与男性有关（症状4）;年龄> 40/45岁（男性/女性;症状1,2,4）;单身/未婚状态（症状2-4）;失业（症状3,4）;临床整体印象（CGI）量表和PANSS总分得分较高（症状1-5）; PANSS阳性症状子量表得分较低（症状1,3）;超过52周的治疗（症状1-3,5）;结论：症状：在常规临床实践中，用抗精神病药治疗的精神分裂症谱系障碍患者中阴性症状的患病率仍然很高，而且似乎与功能较差，失业，病情严重，阳性症状较少，抗精神病药剂量较高。

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