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首页> 外文期刊>The journal of clinical psychiatry >New evidence for the involvement of mitochondrial inheritance in schizophrenia: Results from a cross-sectional study evaluating the risk of illness in relatives of schizophrenia patients
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New evidence for the involvement of mitochondrial inheritance in schizophrenia: Results from a cross-sectional study evaluating the risk of illness in relatives of schizophrenia patients

机译：线粒体遗传参与精神分裂症的新证据：一项评估精神分裂症患者亲属患病风险的横断面研究的结果

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Objective: One of the hypotheses about the genetic factors that contribute to schizophrenia involves mitochondrial DNA (mtDNA), an approximately 16,569-base pair molecule inherited only from the mother. If this hypothesis were true, one would expect a higher frequency of schizophrenia among matrilineal relatives who share mtDNA with a schizophrenia patient than among relatives who do not. This article reports the risk of presenting with schizophrenia, other psychiatric disorders, and conditions related to mitochondrial disorders in relatives who share mtDNA with a schizophrenia patient versus those who do not. Method: We interviewed 100 schizophrenia patients (DSM-IV criteria) and 147 of their first-degree relatives from November 2007 to November 2009 to collect clinical data from patients and from both sides of each patient's pedigree. The study was conducted at of a psychiatric teaching hospital in Reus, Spain. Contingency tables were established, and odds ratios were calculated to estimate relative risk. Results: Relatives who shared mtDNA with a schizophrenia patient had a higher risk of presenting with schizophrenia than those who did not share mtDNA (odds ratio [OR] = 3.05; 95% CI, 1.65-5.72; P < .001). Female but not male relatives who shared mtDNA with a schizophrenia patient also had a higher risk of unipolar depression (OR =10.19; 95% CI, 4.07-32.80; P < .001), panic attack (OR = 15.52; 95% CI, 2.41-643.6; P < .001), and other anxiety disorders (OR = 4.14; 95% CI, 1.84-9.71; P < .001). Some conditions frequently associated with mitochondrial disorders were also more frequent among female relatives who shared mtDNA with a schizophrenia patient than among those who did not. Conclusions: The results of this study support the hypothesis that mtDNA may be involved in schizophrenia. In females, mtDNA could also be involved in the development of other psychiatric and nonpsychiatric conditions. Further studies are needed to confirm the role of mtDNA in psychiatric disorders.
机译：目的：关于导致精神分裂症的遗传因素的一种假设涉及线粒体DNA（mtDNA），线粒体DNA是仅从母亲那里遗传的大约16,569个碱基的分子。如果这一假设成立，那么与精神分裂症患者共享mtDNA的母系亲戚中的精神分裂症患病率要高于没有精神分裂症患者的亲属。本文报道了与精神分裂症患者共享mtDNA的亲戚与未与精神分裂症患者共享mtDNA的亲戚有精神分裂症，其他精神疾病和与线粒体疾病相关的状况的风险。方法：我们采访了2007年11月至2009年11月期间的100例精神分裂症患者（DSM-IV标准）及其147名一级亲属，以收集患者以及每个患者谱系两侧的临床数据。这项研究是在西班牙雷乌斯的一家精神病教学医院进行的。建立了应急表，并计算了优势比以估计相对风险。结果：与不共享mtDNA的亲戚相比，与精神分裂症患者共享mtDNA的亲戚患精神分裂症的风险更高（赔率[OR] = 3.05; 95％CI，1.65-5.72; P <.001）。与精神分裂症患者共享mtDNA的女性而非男性亲属也有较高的单相抑郁风险（OR = 10.19; 95％CI，4.07-32.80; P <.001），惊恐发作（OR = 15.52; 95％CI， 2.41-643.6; P <.001）和其他焦虑症（OR = 4.14; 95％CI，1.84-9.71; P <.001）。与精神分裂症患者共享mtDNA的女性亲属中，与线粒体疾病经常相关的某些情况也比不与精神分裂症患者共享。结论：这项研究的结果支持了线粒体DNA可能与精神分裂症有关的假说。在女性中，mtDNA也可能参与其他精神疾病和非精神疾病的发展。需要进一步的研究来确认mtDNA在精神疾病中的作用。

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