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首页> 外文期刊>The Journal of dermatology >Lymphocutaneous type of nocardiosis caused by Nocardia brasiliensis: a case report and review of primary cutaneous nocardiosis caused by N. brasiliensis reported in Japan.
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Lymphocutaneous type of nocardiosis caused by Nocardia brasiliensis: a case report and review of primary cutaneous nocardiosis caused by N. brasiliensis reported in Japan.

机译：由巴西诺卡氏菌引起的淋巴结膜性诺卡氏病：一例报道和在日本报道由巴西巴西猪笼草引起的原发性皮肤诺卡氏病的综述。

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摘要

Nocardiosis is a mixed suppurative and granulomatous inflammatory disease caused by infection with Nocardia organisms, a group of aerobic actinomycetes. We recently encountered a 25-year-old woman with posttraumatic nocardiosis of the lower extremities. The clinical symptoms noted during her first visit included erythematous swelling of the right knee accompanied by white maceration of the center of the knee and erosions, shallow ulcers and satellite pustules. In addition, multiple erythematous areas (up to the size of the tip of the thumb) were linearly distributed on the right thigh. These lesions were painful, and right inguinal lymphadenopathy was also noted. No lesion was found in internal organs such as the lungs. Histopathologically, signs of nonspecific granulomatous inflammation were observed, as well as several filamentous branching bacilli positive on Grocott stain. The organisms isolated from culture of pus were acid-fast, Gram-positive long rods. The isolated strain was finally identified as Nocardia brasiliensis. The patient was therefore diagnosed with lymphocutaneous type of primary cutaneous nocardiosis caused by N. brasiliensis. Drip infusion of flomoxef sodium was initially performed to treat her condition. Because of exacerbation of erythematous swelling of the right knee and an increase in number of pustules, treatment was switched to oral minocycline hydrochloride therapy. The disease healed 9 weeks after the start of oral minocycline hydrochloride therapy. Our patient was free of systemic immunosuppression and was neither under 10 nor over 65 years of age. She may therefore be considered a rare case of lymphocutaneous type of nocardiosis. We present this case and discuss reported cases of primary cutaneous nocardiosis due to N. brasiliensis in Japan.
机译：诺卡氏病是化脓性和肉芽肿性混合炎性疾病，由诺卡氏菌生物体（一组有氧放线菌）感染引起。我们最近遇到了一名25岁的下肢创伤后型心肌病的妇女。她初次就诊时注意到的临床症状包括右膝红斑肿胀，并伴有膝盖中央的白色浸软和糜烂，浅溃疡和附属脓疱。此外，右大腿上线性分布着多个红斑区域（最大为拇指尖的大小）。这些病变是疼痛的，并且还注意到右腹股沟淋巴结病。在内部器官如肺中未发现病变。在组织病理学上，观察到非特异性肉芽肿性炎症的迹象，以及在Grocott染色上呈阳性的几个丝状分支杆菌。从脓培养物中分离出的生物是耐酸的革兰氏阳性长棒。最终分离出的菌株被鉴定为巴西诺卡氏菌。因此，该患者被诊断为由巴西猪奈瑟氏菌引起的淋巴皮肤型原发性皮肤诺卡氏病。最初进行滴注氟莫昔钠治疗她的病情。由于右膝红斑肿胀加重和脓疱数量增加，治疗方法改为口服盐酸米诺环素。口服米诺环素盐酸盐治疗开始后9周，该病已he愈。我们的患者没有全身免疫抑制，年龄在10岁以下或65岁以上。因此，她可能被认为是淋巴皮肤型诺卡氏病的罕见病例。我们介绍了此病例，并讨论了在日本因巴西奈瑟菌引起的原发性皮肤性心脏病的报道病例。

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