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首页> 外文期刊>The Journal of dermatology >Case of intractable ophiasis type of alopecia areata presumably improved by fexofenadine
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Case of intractable ophiasis type of alopecia areata presumably improved by fexofenadine

机译：非索非那定可能改善难治性精神病型斑秃

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摘要

Alopecia areata (AA), the most common cause of inflammation-induced hair loss, is a T-cell-mediated autoimmune disease restricted to hair follicles. Disease onset is associated with the collapse of hair follicle immune privilege both in humans and in animal models. Ophiasis type AA is one of the severe types of AA, and is characterized by a turban- or snake-like pattern of hair loss, affecting a band-shaped area in the occipital and temporal scalp regions. Ophiasis type AA as well as AA totalis in general results in the worst outcomes with lower frequency of spontaneous remission and poorer responses to conventional therapy than other clinical types of AA. Despite our understanding of the pathophysiology of AA, evidence-based treatments are still limited, especially for patients with severe types of AA. Previous clinical studies have suggested that antihistamines, including fexofenadine and ebastine, have favorable effect in severe AA patients when used concurrently with topical immunotherapy.
机译：斑秃（AA）是炎症引起的脱发的最常见原因，是一种T细胞介导的自身免疫性疾病，仅限于毛囊。疾病的发作与人类和动物模型中毛囊免疫特权的降低有关。眼睑AA型是严重的AA类型之一，其特征是头巾或蛇状脱发，影响枕骨和颞头皮区域的带状区域。与其他临床类型的AA相比，一般而言，OCA型AA和总体AA导致最差的结果，自发缓解的频率较低，并且对常规疗法的反应较差。尽管我们对AA的病理生理学有所了解，但基于证据的治疗仍然有限，尤其是对于严重AA类型的患者。先前的临床研究表明，当与局部免疫疗法同时使用时，抗组胺药（包括非索非那定和依巴斯汀）在严重的AA患者中具有良好的疗效。

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