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首页> 外文期刊>The Journal of dermatology >Clinicopathological features of mycosis fungoides in patients exposed to Agent Orange during the Vietnam War
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Clinicopathological features of mycosis fungoides in patients exposed to Agent Orange during the Vietnam War

机译：越战期间暴露于橘子剂的患者中的真菌病真菌病的临床病理特征

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There are no reports on the clinicopathological features of mycosis fungoides (MF) among veterans exposed to Agent Orange, one of the herbicides used during the Vietnam War. To evaluate the clinical, histopathological and genotypic findings of Vietnam War veterans with MF and a positive history of exposure to Agent Orange, we performed a comparative clinicopathological study between MF patients with a history of Agent Orange exposure and those without a history of Agent Orange exposure. Twelve Vietnam War veterans with MF were identified. The mean interval from Agent Orange exposure to diagnosis was 24.5 years (range, 9-35). Skin lesions were significantly present on exposed and unexposed areas. Most patients (75%) experienced pruritus (mean visual analog scale score of 6.7). MF was manifested by plaques in 10 patients and by lichenification in five. Histopathological features of most cases were consistent with MF. Biopsy specimens also demonstrated irregular acanthosis (66.7%). In the comparative study, MF patients with a history of Agent Orange exposure differed significantly from those without exposure to Agent Orange in demographic and clinical characteristics. In addition, patients with exposure had an increased tendency for lesions in the exposed area. Notably, our patients showed a higher frequency (33.3%) of mycosis fungoides palmaris et plantaris than in previous studies. Histologically, irregular acanthosis was more frequently observed than ordinary MF. Our results indicate that dermatologists should pay close attention to these clinicopathological differences. Careful assessment of history of exposure to defoliants is warranted in some cases suspicious for MF.
机译：没有报道过暴露于越战期间使用的一种除草剂之一的橘子（Agent Orange）中退伍军人体内真菌病（MF）的临床病理特征。为了评估越南战争退伍军人患有MF并接触过Orange的病史为阳性的临床，组织病理学和基因型研究结果，我们对有过Agent Orange接触史的MF患者和未接触过Orange的病史的MF患者进行了比较的临床病理研究。 。确定了12名拥有MF的越战退伍军人。从接触橙色剂到诊断的平均间隔为24.5年（范围9-35）。裸露和未裸露区域明显存在皮肤病变。大多数患者（75％）经历了瘙痒症（平均视觉模拟量表评分为6.7）。 MF在10例患者中有斑块出现，在5例中通过苔藓样化表现出来。大多数病例的组织病理学特征与MF一致。活检标本还显示不规则棘皮症（66.7％）。在比较研究中，有橘子接触史的MF患者在人口统计学和临床​​特征上与未接触橘子的患者有显着差异。另外，暴露的患者在暴露区域的病变增加的趋势。值得注意的是，我们的患者比以前的研究显示出较高的霉菌性棕榈果真菌病（33.3％）发生率。从组织学上看，不规则棘皮症比普通MF更为常见。我们的结果表明，皮肤科医生应密切注意这些临床病理差异。在某些情况下，应仔细评估脱叶剂的暴露历史，怀疑其MF。

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