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首页> 外文期刊>The Journal of dermatology >Dermatitis herpetiformis in a Japanese patient with anaplastic large cell lymphoma.
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Dermatitis herpetiformis in a Japanese patient with anaplastic large cell lymphoma.

机译：日本变性间变性大细胞淋巴瘤患者的疱疹样皮炎。

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摘要

We report a 73-year-old Japanese man with dermatitis herpetiformis which developed after diagnosis of anaplastic large cell lymphoma. The patient suffered fever, sweating, shivering, and multiple enlarged cervical lymph nodes. The diagnosis of anaplastic large cell lymphoma was confirmed by the histologic features of a biopsied cervical lymph node. The patient underwent combination chemotherapy. However, one month after the initial therapy, pruritic erythematous skin lesions with peripheral vesicles appeared on his buttocks. A skin biopsy showed subepidermal blister formation associated with polymorphonuclear and mononuclear cell infiltrates. Direct immunofluorescence examination of the area adjacent to the lesion showed granular deposits of IgA at the dermoepidermal junction. While it is well-known that dermatitis herpetiformis can develop into lymphoma, there have been only a few reports of its appearance after a diagnosis of lymphoma. This case suggests that dermatitis herpetiformis may be induced by anaplastic large cell lymphoma.
机译：我们报告了一名73岁的日本男子，患有疱疹样皮炎，在诊断为间变性大细胞淋巴瘤后发展。该患者发烧，出汗，发抖，并有多个颈部淋巴结肿大。间变性大细胞淋巴瘤的诊断已通过活检宫颈淋巴结的组织学特征得到证实。该患者接受了联合化疗。然而，在初始治疗一个月后，他的臀部出现了瘙痒性红斑性皮肤损伤和周围囊泡。皮肤活检显示与多形核和单核细胞浸润相关的表皮下水疱形成。对病变附近区域的直接免疫荧光检查显示，真皮表皮交界处有IgA颗粒状沉积物。虽然众所周知，疱疹样皮炎可以发展成淋巴瘤，但只有少数报道表明在诊断出淋巴瘤后出现了皮疹。这种情况表明，变性间变性大细胞淋巴瘤可能引起疱疹样皮炎。

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