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首页> 外文期刊>The Journal of dermatology >Mutations in the drug resistance-determining region of Mycobacterium lepromatosis isolated from leprosy patients in Mexico
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Mutations in the drug resistance-determining region of Mycobacterium lepromatosis isolated from leprosy patients in Mexico

机译：从墨西哥麻风病人中分离出来的麻风分枝杆菌的耐药决定区突变

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摘要

Mycobacterium lepromatosis, an independent species from Mycobacterium leprae, has been found to be a causative agent for diffuse lepromatous leprosy (DLL) in Mexico, but remains poorly studied. Here, the drug resistance-determining regions (DRDR) of folP1, rpoB and gyrA (conferring resistance to dapsone, rifampicin and quinolone, respectively) in M. lepromatosis from leprosy patients in Mexico were characterized. No mutations or silent mutations were found at previously characterized major sites in DRDR of M. lepromatosis. However, a non-synonymous mutation was found in codon 54 between two major sites of the folP1 DRDR in M. lepromatosis sequences. All M. lepromatosis isolates showed CAG sequence in codon 54 of folP1. Because the next codons 53 and 55 are known as major mutation sites for drug resistance, more detailed analysis using more samples is needed to determine whether it influences susceptibility to dapsone and/or efficiency of folate biosynthesis in M. lepromatosis or not.
机译：麻风分枝杆菌是一种独立于麻风分枝杆菌的物种，在墨西哥已被发现是弥散性麻风麻风病（DLL）的病原体，但仍缺乏研究。在此，对墨西哥麻风病患者麻风分枝杆菌中folP1，rpoB和gyrA（分别赋予氨苯砜，利福平和喹诺酮的耐药性）的耐药性决定区域（DRDR）进行了表征。在麻风分枝杆菌DRDR先前鉴定的主要位点未发现突变或沉默突变。但是，在麻风支原体序列中的folP1 DRDR的两个主要位点之间的54号密码子中发现了一个非同义突变。所有麻风分枝杆菌分离株均在folP1的54号密码子中显示CAG序列。由于下一个密码子53和55被称为耐药性的主要突变位点，因此需要使用更多样品进行更详细的分析，以确定其是否影响氨苯砜敏感性和/或麻风分枝杆菌中叶酸生物合成的效率。

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