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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Application of sepsis calculator in newborns with suspected infection
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Application of sepsis calculator in newborns with suspected infection

机译：败血症计算器在疑似感染新生儿中的应用

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Objective: To compare actual antibiotic use to the stratification based on the sepsis calculator in newborns with suspected early onset sepsis (EOS). To investigate differences in EOS risk and vital signs between newborns that received early (<12h) versus late antibiotics (12h of life).Methods: Newborns born 34 weeks gestation in 2014 treated with antibiotics started within 72h after birth were included. We calculated the risk per 1000 live births and retrospectively assigned each newborn to one of four recommended categories using the sepsis calculator.Results: There were 2094 newborns, 111 (5.3%) received antibiotics and 108 newborns were included. The incidence of culture-proven EOS was 0.096%. In 57 newborns, the advice of the sepsis calculator was not to start antibiotic therapy. Antibiotic treatment was started early in 66 (61%) and late in 42 (39%) newborns. In the late treatment group, clinical condition deteriorated, including two newborns with culture-proven EOS. Tachypnea and respiratory distress were significantly more present.Conclusion: Antibiotic use could be reduced by more than 50%. Newborns with initial low sepsis risk score clinically deteriorated beyond 12h of life. Continuous good clinical observation remains very important. Prospective validation is necessary to evaluate the safety of this approach.
机译：目的：根据脓毒症计算器，比较怀疑可疑的早发性败血症（EOS）的新生儿的实际抗生素使用与分层的比较。调查早期（<12h）与晚期（12h）的新生儿在EOS风险和生命体征上的差异。方法：纳入2014年妊娠34周的新生儿，在出生后72h内开始接受抗生素治疗。我们计算了每1000例活产婴儿的风险，并使用败血症计算器对每个新生儿进行回顾性归类为四个推荐类别之一。结果：共有2094例新生儿，111例（5.3％）接受了抗生素和108例新生儿。经文化验证的EOS发生率为0.096％。在57名新生儿中，脓毒症计算器的建议是不开始抗生素治疗。抗生素治疗在66例（61％）的早期开始，在42例（39％）的新生儿后期开始。在晚期治疗组中，临床状况恶化，包括两个经培养证实的EOS的新生儿。呼吸急促和呼吸窘迫的发生率明显更高。结论：抗生素使用量可减少50％以上。最初败血症风险评分低的新生儿在生命超过12小时后临床恶化。持续良好的临床观察仍然非常重要。前瞻性验证对于评估此方法的安全性是必要的。

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