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首页> 外文期刊>Chinese journal of digestive diseases >In view of an optimal gut antifungal therapeutic strategy: an in vitro susceptibility and toxicity study testing a novel phyto-compound.
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In view of an optimal gut antifungal therapeutic strategy: an in vitro susceptibility and toxicity study testing a novel phyto-compound.

机译：鉴于最佳的肠道抗真菌治疗策略：测试新型植物化合物的体外药敏和毒性研究。

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OBJECTIVE: In view of the raising concern for gut fungal infection, the aim of the present research was to carry out a systematic in vitro study testing the antifungal activity and possible toxicity of a polygodyal-anethole compound (Kolorex) in several strains of Candida albicans and in other fungal pathogens. METHODS: The in vitro susceptibility tests were carried out on 4 strains of C. albicans (C. krusei, C. lipolytica, C. tropicalis, C. utilis), Aspergillus flavus and A. fumigatus. Cultures were also analyzed by varying medium, pH and inoculum size, and a time-course killing test was carried out. RESULTS: In the present study the polygodyal-anethole compound showed remarkable in vitro activity against the most common fungi, which was significantly better than polygodyal alone. Moreover, such mixture compound was shown to exert its activity against a wide spectrum of fungi, including C. lipolytica and C. tropicalis, which required significantly higher MIC of polygodyal to be unfeasible in clinical application. The activity of the polygodyal-anethole compound was significantly better than polygodyal alone with high inoculum size and low pH. Moreover, it proved to exert a significantly faster biological activity against low inoculum. CONCLUSIONS: This study suggests that the mixture compound Kolorex has a very good profile of antifungal activity in terms of effectiveness and spectrum of action while being devoid of any significant toxicity.
机译：目的：鉴于对肠道真菌感染的关注日益增加，本研究的目的是进行系统的体外研究，以测试多糖-茴香脑化合物（Kolorex）在几种白色念珠菌菌株中的抗真菌活性和可能的​​毒性。和其他真菌病原体。方法：对4株白色念珠菌（C. krusei，解脂梭菌，C.tropicis，C。utilis），黄曲霉和烟曲霉进行了体外药敏试验。还通过改变培养基，pH和接种物大小来分析培养物，并进行了时程杀死试验。结果：在本研究中，多糖-茴香脑化合物对最常见的真菌显示出显着的体外活性，明显优于单独的多糖。此外，已表明这种混合物化合物对包括解脂梭状芽胞杆菌和热带梭状芽孢杆菌在内的广谱真菌发挥其活性，这要求在临床应用中不可行的多糖的MIC要高得多。高接种量和低pH值的聚gogodyal-茴香脑化合物的活性明显优于单独的polygodyal。此外，它被证明对低接种量具有明显更快的生物学活性。结论：这项研究表明，混合物Kolorex在有效性和作用谱方面具有很好的抗真菌活性，同时没有任何明显的毒性。

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