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首页> 外文期刊>The Journal of investigative dermatology. >Deep-sequencing analysis reveals that the miR-199a2/214 cluster within DNM3os represents the vast majority of aberrantly expressed MicroRNAs in sézary syndrome
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Deep-sequencing analysis reveals that the miR-199a2/214 cluster within DNM3os represents the vast majority of aberrantly expressed MicroRNAs in sézary syndrome

机译：深度测序分析显示DNM3os中的miR-199a2 / 214簇代表了塞氏病综合征中绝大多数异常表达的MicroRNA

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摘要

MicroRNA (miR) is a class of non-coding RNA, modulating gene expression through negative regulation of target gene expression. Currently, > 1,000 human miRs have been identified which can have crucial roles during (tuning of) T-cell activation and differentiation (Lindsay, 2008; Lodish et al., 2008), and there is increasing evidence for a role of miRs in the pathogenesis of lymphoma and leukemia (Croce, 2009).Recent miR array studies indicate that a considerable amount of miRs show aberrant expression in cutaneous T-cell lymphoma (CTCL), including Sezary (Sz) syndrome (Ballabio ef al., 2010; Narducci et al., 2011; Ralfkiaer ef al., 2011; van Kester et al., 2011). However, findings from these array-based analyses are not fully consistent, perhaps as a result from variant technological approaches and disadvantages such as background noise and cross-hybridization problems. These drawbacks can be overcome by next generation (deep) sequencing, which offers increased sensitivity and specificity, and has an unlimited detecting range.
机译：MicroRNA（miR）是一类非编码RNA，通过对靶基因表达的负调控来调节基因表达。目前，已鉴定出超过1,000种人类miR在T细胞活化和分化（调节）过程中起着关键作用（Lindsay，2008; Lodish等，2008），并且越来越多的证据表明miR在人类T细胞活化和分化中起着重要作用。淋巴瘤和白血病的发病机理（Croce，2009）。最近的miR阵列研究表明，大量的miR在皮肤T细胞淋巴瘤（CTCL）中表现出异常表达，包括Sezary（Sz）综合征（Ballabio等，2010; Narducci等人，2011; Ralfkiaer等人，2011; van Kester等人，2011）。但是，这些基于阵列的分析结果并不完全一致，这可能是由于各种技术方法以及背景噪声和交叉杂交问题等缺点所致。这些缺点可以通过下一代（深度）测序来克服，这种测序可提高灵敏度和特异性，并具有无限的检测范围。

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