Pegylated and Conventional Interferon-alpha Induce Comparable Transcriptional Responses and Inhibition of Tumor Growth in a Human Melanoma SCID Mouse Xenotransplantation Model.

Pehamberger H

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Pegylated and Conventional Interferon-alpha Induce Comparable Transcriptional Responses and Inhibition of Tumor Growth in a Human Melanoma SCID Mouse Xenotransplantation Model.

机译：在人黑素瘤SCID小鼠异种移植模型中，聚乙二醇化和常规干扰素-α诱导可比的转录反应和肿瘤生长的抑制。

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Interferon-alpha (IFN-alpha) is widely used for the treatment of viral infections and primary cancers. In the present study, we investigated whether the anti-proliferative activity of IFN-alpha is capable of inhibiting melanoma tumor development in the absence of protective immune responses in a severe combined immunodeficiency (SCID) mouse model. Mice treated with either regular (100 microg/ 3 times per week) or pegylated (300 microg/ once weekly) human IFN-alpha 2a showed a marked reduction in tumor weight after 4 wk of treatment. Tumor weight in pegylated and conventional IFN-alpha-treated animals was reduced by 61% and 67%, respectively, as compared to saline control (both p

机译：干扰素-α（IFN-α）被广泛用于治疗病毒感染和原发性癌症。在本研究中，我们调查了在严重的联合免疫缺陷（SCID）小鼠模型中，在没有保护性免疫应答的情况下，IFN-α的抗增殖活性是否能够抑制黑色素瘤肿瘤的发展。常规（100微克/每周3次）或聚乙二醇化（300微克/每周一次）人IFN-α2a治疗的小鼠在治疗4周后，肿瘤重量显着降低。与盐水对照组相比，聚乙二醇化和常规IFN-α处理的动物的肿瘤重量分别降低了61％和67％。在IFN治疗的肿瘤中观察到增殖的减少和凋亡性肿瘤细胞的增加。在治疗4周后，将DNA微阵列应用于分析肿瘤中的转录反应，并差异表达了约90个基因的子集。二十四个新的和五个已知的干扰素诱导基因被上调，而65个基因被下调。 IFN-α和聚乙二醇化IFN-α的直接比较未显示出肿瘤生长抑制作用的任何显着差异，表明这种新型且更稳定的IFN类在功能上是等效的。尽管聚乙二醇化和常规IFN-α在结构上存在差异，但两种药物在人黑素瘤异种移植物中均引起相似的转录反应。

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《The Journal of investigative dermatology.》 |2004年第4期|共6页
作者
Pehamberger H;
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正文语种 eng
中图分类皮肤病学与性病学;
关键词
Neoplasms; Melanoma; Human; therapeutic aspects; Interferon-alpha; 肿瘤; 黑色素瘤; 干扰素α;

机译：Neoplasms;Melanoma;Human;therapeutic aspects;Interferon-alpha;肿瘤;黑色素瘤;干扰素α;

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1. Pegylated and Conventional Interferon-alpha Induce Comparable Transcriptional Responses and Inhibition of Tumor Growth in a Human Melanoma SCID Mouse Xenotransplantation Model. [J] . Pehamberger H The Journal of investigative dermatology. . 2004,第4期

机译：在人黑素瘤SCID小鼠异种移植模型中，聚乙二醇化和常规干扰素-α诱导可比的转录反应和肿瘤生长的抑制。
2. Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model. [J] . Thallinger C, Wolschek MF, Wacheck V, The Journal of investigative dermatology. . 2003,第6期

机译：Mcl-1反义疗法可在SCID小鼠异种移植模型中对人类黑素瘤产生化学敏感性。
3. Paclitaxel encapsulated in cationic liposomes diminishes tumor angiogenesis and melanoma growth in a "humanized" SCID mouse model. [J] . Kunstfeld R, Wickenhauser G, Michaelis U, The Journal of investigative dermatology. . 2003,第3期

机译：在“人源化” SCID小鼠模型中，封装在阳离子脂质体中的紫杉醇减少了肿瘤血管生成和黑色素瘤的生长。
4. Sustained delivery of antisense oligonucleotides via hydrogels demonstrate efficacy in a human gastric cancer SCID mouse tumor model [C] . S.P. Barman, D. Wang, M.L.Hedley Annual meeting of the Society For Biomaterials . 2003

机译：通过水凝胶持续递送反义寡核苷酸在人类胃癌SCID小鼠肿瘤模型中显示出功效
5. Adenovirus- and cationic-lipid-mediated intratumoral gene transfer and natural killer cell activity in a SCID mouse melanoma tumor model. [D] . Clark, Paul Robert. 1999

机译：在SCID小鼠黑素瘤肿瘤模型中，腺病毒和阳离子脂质介导的肿瘤内基因转移和自然杀伤细胞活性。
6. Systemic Delivery of Tumor-Targeted Bax-Derived Membrane-Active Peptides for the Treatment of Melanoma Tumors in a Humanized SCID Mouse Model [O] . Anastassia Karageorgis, Michaël Claron, Romain Jugé, 2017

机译：在人源化SCID小鼠模型中系统性递送靶向肿瘤的Bax衍生的膜活性肽用于治疗黑色素瘤。
7. Pegylated and Conventional Interferon-α Induce Comparable Transcriptional Responses and Inhibition of Tumor Growth in a Human Melanoma SCID Mouse Xenotransplantation Model [O] . Krepler Clemens, Certa Ulrich, Wacheck Volker, 2004

机译：聚乙二醇化和常规干扰素-α在人黑素瘤SCID小鼠异种移植模型中诱导可比的转录反应和肿瘤生长的抑制。

Pegylated and Conventional Interferon-alpha Induce Comparable Transcriptional Responses and Inhibition of Tumor Growth in a Human Melanoma SCID Mouse Xenotransplantation Model.

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