...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of investigative dermatology. >UVB-Irradiated Dendritic Cells Fail to Tolerize Murine CD8 Naive or Effector T Cells.
【24h】

UVB-Irradiated Dendritic Cells Fail to Tolerize Murine CD8 Naive or Effector T Cells.

机译：UVB照射的树突状细胞无法耐受鼠CD8幼稚或效应T细胞。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

UVB radiation has been shown to induce T cell tolerance most likely via modulation of the function of antigen-presenting cells like dendritic cells (DC), which are therefore of interest for vaccination therapy. Since little is known about the effects of UVB-irradiated dendritic cells (UVB-DC) on CD8(+) T cells, which are the dominant effectors in various allergic and autoimmune diseases, we have investigated the potential of low dose UVB (100-200 J per m(2)) irradiated bone marrow-derived dendritic cells to induce tolerance in murine CD8(+) T cells specific for the contact allergen trinitrophenyl (TNP) or for a viral peptide. In contrast to the previously reported successful tolerization of primed CD4(+) Th1 cells, neither naive CD8(+) T cells nor CD8(+) Tc1 effector cells or established CD8(+) T cell clones could be tolerized by TNP-modified or peptide-pulsed UVB-DC in vitro or in vivo. We observed, however, a reduced capacity of UVB-DC to prime naive CD8(+) T cells. Our data demonstrate an important difference in the susceptibility of CD4(+) and CD8(+) T cells for tolerance induction using low-dose UVB-irradiated DC and have implications for DC therapy of CD8(+) T cell-mediated diseases.
机译：已经表明，UVB辐射最有可能通过调节抗原呈递细胞（如树突状细胞（DC））的功能来诱导T细胞耐受性，因此对于疫苗接种治疗很重要。由于对UVB辐射的树突状细胞（UVB-DC）对CD8（+）T细胞的影响知之甚少，CD8（+）T细胞是各种变应性和自身免疫性疾病的主要效应物，因此我们研究了低剂量UVB的潜力（100-每m（2））辐照的骨髓树突状细胞200 J，以诱导对接触性变应原三硝基苯基（TNP）或病毒肽具有特异性的鼠CD8（+）T细胞的耐受性。与先前报道的成功耐受初免的CD4（+）Th1细胞相反，TNP修饰的TNP修饰的CD8（+）T细胞或CD8（+）Tc1效应细胞或已建立的CD8（+）T细胞克隆均不能耐受。在体外或体内用肽脉冲处理的UVB-DC。但是，我们观察到，UVB-DC对初生幼稚CD8（+）T细胞的能力下降。我们的数据表明，CD4（+）和CD8（+）T细胞在使用低剂量UVB辐照的DC诱导耐受性方面的敏感性上存在重要差异，并且对DC8（+）T细胞介导的疾病的DC治疗有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号