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首页> 外文期刊>The Journal of investigative dermatology. >Lack of a role for cross-reacting anti-thyroid antibodies in chronic idiopathic urticaria.
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Lack of a role for cross-reacting anti-thyroid antibodies in chronic idiopathic urticaria.

机译：在慢性特发性荨麻疹中缺乏交叉反应的抗甲状腺抗体的作用。

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摘要

The etiology of chronic idiopathic urticaria (CIU) is attributed to autoantibodies directed against the alpha-chain of the high-affinity IgE receptor (FcepsilonRIalpha) or IgE on mast cells in 30-60% of patients. Approximately 30% of CIU patients have Hashimoto's thyroiditis (HT). We investigated the pathophysiologic relationship of anti-thyroid and anti-FcepsilonRIalpha antibodies. Nine individuals with both CIU and HT underwent autologous serum skin testing (ASST) and sera were assayed for thyroid autoantibodies, thyroid-stimulating hormone, and anti-FcepsilonRIalpha antibodies. Serum samples were studied for their ability to activate a human mast cell line (LUVA) as determined by cysteinyl leukotriene (CysLT) production. Experiments were performed to determine whether epitope cross-reactivity could explain the high incidence of HT found in CIU patients. A significant proportion of CIU patients had a positive ASST (nine of six) and anti-FcepsilonRIalpha antibodies (six of nine). Incubation of patient sera with FcepsilonRIalpha, but not thyroglobulin or thyroid peroxidase, resulted in the decreased ability to detect anti-FcepsilonRIalpha antibodies. Incubation with thyroid antigens did not inhibit CysLT production by mast cells. Epitopic cross-reactivity does not explain the increased prevalence of HT found in CIU patients. The frequent concurrence of HT and CIU likely reflects a genetic tendency toward autoimmune diseases.
机译：慢性特发性荨麻疹（CIU）的病因归因于针对30-60％患者肥大细胞上高亲和力IgE受体（FcepsilonRIalpha）或IgE的α链的自身抗体。大约30％的CIU患者患有桥本甲状腺炎（HT）。我们调查了抗甲状腺和抗FcepsilonRIalpha抗体的病理生理关系。对9名同时患有CIU和HT的个体进行了自体血清皮肤测试（ASST），并检测了血清中的甲状腺自身抗体，促甲状腺激素和抗FcepsilonRIalpha抗体。通过半胱氨酰白三烯（CysLT）的生产来研究血清样品激活人类肥大细胞系（LUVA）的能力。进行实验以确定表位交叉反应是否可以解释CIU患者中HT的高发生率。很大一部分CIU患者的ASST阳性（六分之九）和抗FcepsilonRIalpha抗体（六分之六）。将患者血清与FcepsilonRIalpha（而非甲状腺球蛋白或甲状腺过氧化物酶）一起孵育，导致检测抗FcepsilonRIalpha抗体的能力降低。与甲状腺抗原一起孵育不会抑制肥大细胞产生CysLT。表位交叉反应性不能解释在CIU患者中发现的HT患病率增加。 HT和CIU的频繁并发可能反映了自身免疫性疾病的遗传倾向。

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