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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger.
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Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger.

机译：食欲素通过激活钠钙交换剂来激发弓形核的GABA能神经元。

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摘要

The neuropeptides orexins/hypocretins are essential for normal wakefulness and energy balance, and disruption of their function causes narcolepsy and obesity. Although much is known of the role of orexins in sleep/wake behavior, it remains unclear how they stimulate feeding and metabolism. One of the main targets of orexinergic neurons is the arcuate nucleus (ARC) of the hypothalamus, which plays a key role in feeding and energy homeostasis. By combining patch-clamp and RT-multiplex PCR analysis of individual neurons in mouse brain slices, we show that an electrophysiologically distinct subset of ARC neurons coexpress orexin receptors and glutamate decarboxylase-67 and are excited by orexin. Acting on postsynaptic orexin type 2 receptors, orexin activates a sodium-calcium exchange current, thereby depolarizing the cell and increasing its firing frequency. Because GABA is a potent stimulus for feeding, in both the ARC and its main projection site, these results suggest a mechanism for how orexin may control appetite.
机译：神经肽orexins / hypocretins对于正常的清醒和能量平衡至关重要，其功能破坏会导致发作性睡病和肥胖。尽管人们对食欲素在睡眠/苏醒行为中的作用已广为人知，但仍不清楚它们如何刺激进食和代谢。下丘脑的弓形核（ARC）是食欲能神经元的主要靶标之一，在进食和能量稳态中起着关键作用。通过结合膜片钳和RT多重PCR分析小鼠脑片中单个神经元，我们表明ARC神经元的电生理学独特子集共表达orexin受体和谷氨酸脱羧酶67，并由orexin激发。作用于突触后2型orexin受体，orexin激活钠钙交换电流，从而使细胞去极化并增加其放电频率。因为GABA是ARC及其主要投射部位的一种有效的进食刺激物，所以这些结果表明了orexin如何控制食欲的机制。

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