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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Inferior olive oscillations gate transmission of motor cortical activity to the cerebellum.
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Inferior olive oscillations gate transmission of motor cortical activity to the cerebellum.

机译：下橄榄振荡使运动皮层活动传递到小脑。

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Inferior olivary (IO) neurons display spontaneous oscillatory activity, yet the importance of these oscillations for shaping the responses of this system to its afferents is uncertain. We used multiple electrode recording of crus 2a Purkinje cell complex spikes (CSs) in ketamine-xylazine-anesthetized rats to investigate olivocerebellar responses to activation of motor cortico-olivary pathways. Trains of electrical stimuli were applied to the motor cortex at frequencies between 4 and 30 Hz. Various frequency-response curves were observed, with the most common types being unimodal with a maximum at 9.5 +/- 2.3 Hz and bimodal with peaks at 8.9 +/- 1.0 and 15.1 +/- 1.3 Hz. To determine whether IO oscillatory properties underlie the resonance peaks in the frequency-response curves, apamin and charybdotoxin were injected into the IO. These toxins, which weaken and enhance spontaneous IO oscillations, respectively, had corresponding effects on the sharpness of resonance peaks. Next, the variation of CS entrainment patterns with frequency was investigated to characterize the nature of the IO oscillator. Low-frequency (4 Hz) stimulation was relatively ineffective in entraining CS activity. Between 4 and 30 Hz, two predominant entrainment patterns emerged. For low-frequency (4-6 Hz) and high-frequency (17-30 Hz) ranges, a 1:2 entrainment dominated, whereas in the intermediate range (6-17 Hz), 1:1 entrainment was most prevalent. These results indicate that IO neurons respond as nonlinear oscillators to afferent signals.
机译：下橄榄（IO）神经元表现出自发的振荡活动，但这些振荡对于影响该系统对其传入反应的响应的重要性尚不确定。我们使用氯胺酮-甲苯噻嗪麻醉的大鼠中的小腿2a Purkinje细胞复合物尖峰（CSs）的多电极记录来研究小脑小脑对运动皮质-橄榄腺通路激活的反应。一系列电刺激以4到30 Hz之间的频率施加到运动皮层。观察到各种频率响应曲线，最常见的类型是单峰的，最大峰值为9.5 +/- 2.3 Hz，而双峰的峰值为8.9 +/- 1.0和15.1 +/- 1.3 Hz。为了确定IO振荡特性是否是频率响应曲线中共振峰的基础，将apapamin和Charybdotoxin注入IO。这些分别减弱和增强自发IO振荡的毒素对共振峰的清晰度具有相应的影响。接下来，研究了CS夹带模式随频率的变化，以表征IO振荡器的特性。低频刺激（4 Hz）在训练CS活动方面相对无效。在4到30 Hz之间，出现了两个主要的夹带模式。对于低频（4-6 Hz）和高频（17-30 Hz）范围，夹带为1：2，而在中等范围（6-17 Hz）中，1：1夹带最为普遍。这些结果表明，IO神经元作为非线性振荡器响应传入信号。

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