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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Central structures necessary and sufficient for ingestive and glycemic responses to Urocortin I administration.
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Central structures necessary and sufficient for ingestive and glycemic responses to Urocortin I administration.

机译：对Urocortin I的摄取和血糖反应必要和足够的中心结构。

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摘要

CNS delivery of Urocortin I (UcnI), a member of the corticotropin-releasing factor family, suppresses feeding behavior and increases plasma glucose. The sites of action necessary and sufficient for these responses remain unclear. The contribution of the caudal brainstem was explored using chronically maintained decerebrate (CD) and neurologically intact control rats given fourth-ventricle injections of UcnI. Ingestive and glycemic responses were evaluated, and Fos immunoreactivity was measured in the paraventricular nucleus of the hypothalamus (PVN), the parabrachical nucleus (PBN), the rostral ventrolateral medulla (RVLM), and the nucleus of the solitary tract (NTS). CD rats, like the neurologically intact controls, decreased intraoral food intake and had elevated plasma glucose in response to Unc1 injections, indicating that forebrain structures are not required for these behavioral and physiological actions of UcnI. Fos immunohistochemistry, however, revealed notable differences in the pattern of UcnI-induced activation between intact and CD rats. UcnI-related activation was observed in each of the four aforementioned brain areas of neurologically intact rats but only in the NTS of CD rats. The intact behavioral and physiological responses to UcnI in the absence of neural activation in the PVN, PBN, and RVLM help limit the list of structures necessary for the stimulation and mediation of these responses to UcnI and suggest that the NTS may serve as a primary site of UcnI action.
机译：促肾上腺皮质激素释放因子家族成员Urocortin I（UcnI）的CNS传递抑制了进食行为并增加了血浆葡萄糖。这些响应所必需和足够的行动地点仍然不清楚。使用长期维持的小脑（CD）和神经功能完好的对照组大鼠进行第四脑室注射UcnI，探讨了尾脑干的作用。评估了摄入和血糖反应，并测量了下丘脑室旁核（PVN），臂丛旁核（PBN），腹侧腹侧延髓（RVLM）和孤立道核（NTS）的Fos免疫反应性。 CD大鼠，如神经学上完整的对照一样，减少了口内食物的摄入，并响应Unc1注射而使血浆葡萄糖升高，表明UcnI的这些行为和生理作用不需要前脑结构。 Fos免疫组织化学显示，完整大鼠和CD大鼠之间UcnI诱导的激活模式存在显着差异。在神经完整的大鼠的上述四个大脑区域的每一个中都观察到了UcnI相关的激活，但仅在CD大鼠的NTS中观察到了。在PVN，PBN和RVLM中没有神经激活的情况下，对UcnI的完整行为和生理反应有助于限制刺激和介导对UcnI的这些反应所必需的结构清单，并暗示NTS可能是主要部位UcnI行动。

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