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首页> 外文期刊>The Annals of otology, rhinology, and laryngology >Ki-67 proliferation rate as a prognostic marker in major salivary gland carcinomas.
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Ki-67 proliferation rate as a prognostic marker in major salivary gland carcinomas.

机译：Ki-67增殖率作为主要唾液腺癌的预后指标。

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OBJECTIVES: The study was performed to evaluate the prognostic relevance of cell proliferation associated with Ki-67/ Mib-1 immunostaining in malignant tumors of the major salivary glands. METHODS: Cell proliferation was evaluated by Mib-1 antibody against Ki-67 antigen in 41 patients with cancer of the parotid or submandibular glands, including 14 acinic cell carcinomas, 12 ductal carcinomas, 7 mucoepidermoid carcinomas, 5 carcinomas ex pleomorphic adenoma, 1 adenoid cystic carcinoma, 1 undifferentiated carcinoma, and 1 polymorphous low-grade adenocarcinoma. RESULTS: Patients with Ki-67 values of more than 15% and those with Ki-67 values of 15% or less differed both in disease-free survival (p < 0.001) and in overall survival (p < 0.001). We evaluated the association between Ki-67 and time to recurrence in correlation to age, sex, ductal histotype, and N stage; the Cox regression model was significant (p = 0.013). In the group of patients with T1 and T2 cancers, those with Ki-67 values of 15% or less had better survival rates than did those with Ki-67 values of more than 15% (p = 0.004). In the group of patients with N0 cancers, those with Ki-67 values of 15% or less had a better survival than did those with Ki-67 values of more than 15% (p < 0.001). CONCLUSIONS: To our knowledge, this is the first study to stratify different risk classes in early T1-T2 or N0 malignant tumors of the major salivary glands that identified aggressive lesions with elevated Ki-67 expression at an initial stage.
机译：目的：本研究旨在评估主要唾液腺恶性肿瘤中与Ki-67 / Mib-1免疫染色相关的细胞增殖的预后相关性。方法：用抗Ki-67抗原的Mib-1抗体评​​估41例腮腺或下颌下腺癌患者的细胞增殖，其中包括14例腺癌细胞，12例导管癌，7例粘液表皮样癌，5例多形性腺瘤，1例腺样体癌。囊性癌，1例未分化癌和1例多态性低度腺癌。结果：Ki-67值大于15％的患者和Ki-67值小于或等于15％的患者在无病生存期（p <0.001）和总生存期（p <0.001）方面均存在差异。我们评估了Ki-67与复发时间之间的相关性，并与年龄，性别，导管组织类型和N期相关。 Cox回归模型显着（p = 0.013）。在患有T1和T2癌症的患者组中，Ki-67值小于或等于15％的患者比Ki-67值大于15％的患者具有更好的生存率（p = 0.004）。在患有N0癌的患者组中，Ki-67值小于或等于15％的患者比Ki-67值大于15％的患者具有更好的生存率（p <0.001）。结论：据我们所知，这是第一个对主要唾液腺的早期T1-T2或N0恶性肿瘤的不同风险类别进行分层的研究，该研究在初始阶段就发现了Ki-67表达升高的侵袭性病变。

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