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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Valacyclovir and Postherpetic Neuralgia
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Valacyclovir and Postherpetic Neuralgia

机译：伐昔洛韦和疱疹后神经痛

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Objective: To describe the role of valacyclovir in the treatment of acute herpes zoster pain and its effect in postherpetic neuralgia.Data Sources: A literature search was conducted on MEDLINE (1980-October 2003). Search terms included valacyclovir, postherpetic neuralgia, treatment, acyclovir, and valacyclovir.Study Selection and Data Extraction: Articles describing use of valacyclovir in the treatment of herpes zoster, with focus upon alleviation of acute zoster pain and postherpetic neuralgia, and articles describing use of valacyclovir for this indication in comparison with other antivirals were evaluated.Data Synthesis: Four studies discussing the use of valacyclovir in the treatment of herpes zoster with focus on herpetic pain and postherpetic neuralgia were identified. All of these studies reported that valacyclovir is an effective treatment for herpes zoster and alleviates associated pain significantly faster than acyclovir, presumably due to its greater bioavailability. Valacyclovir likely results in a higher adherence rate than acyclovir because it is closed 3 versus 5 times daily. Interestingly, the severity of pain was not significantly different between the 2 treatments, only the duration. Finally, one study showed that valacyclovir is equally as effective as famciclovir in alleviating pain associated with herpes zoster.Conclusions: Valacyclovir 1 g given orally 3 times a day for 7 days is effective in the treatment of herpes zoster. It is superior to acyclovir 800 mg given orally 5 times a day for 7 days and equivalent to famciclovir 500 mg given orally 3 times a day for 7 days in alleviating acute zoster pain and postherpetic neuralgia.
机译：目的：描述伐昔洛韦在急性带状疱疹疼痛治疗中的作用及其在带状疱疹后神经痛中的作用。数据来源：对MEDLINE进行的文献检索（1980年10月至2003年10月）。检索词包括伐昔洛韦，带状疱疹后神经痛，治疗，阿昔洛韦和伐昔洛韦。研究选择和数据提取：描述伐拉昔洛韦用于治疗带状疱疹的文章，着重减轻急性带状疱疹疼痛和带状疱疹后神经痛的文章，以及描述与其他抗病毒药物相比，评价了伐昔洛韦与这种药物的适应症。数据综合：确定了四项讨论伐昔洛韦在带状疱疹治疗中的使用的研究，重点是疱疹性疼痛和疱疹后神经痛。所有这些研究均表明，伐昔洛韦是一种治疗带状疱疹的有效方法，与阿昔洛韦相比，其缓解疼痛的速度明显快于阿昔洛韦，这可能是由于其生物利用度更高。与阿昔洛韦相比，伐昔洛韦可能比阿昔洛韦具有更高的依从率，因为每天封闭3次，而不是5次。有趣的是，两种治疗之间疼痛的严重程度并没有显着差异，只是持续时间不同。最后，一项研究表明伐昔洛韦在缓解带状疱疹相关疼痛方面与泛昔洛韦同样有效。结论：伐拉昔洛韦每天1次口服3次，每天3次，连续7天，可有效治疗带状疱疹。在减轻急性带状疱疹疼痛和带状疱疹后神经痛方面，它优于每天口服5次，连续7天的阿昔洛韦800毫克，相当于每天口服3次，连续7天的泛昔洛韦500毫克。

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