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首页> 外文期刊>The Journal of Nutritional Biochemistry >Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation.
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Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation.

机译：绿茶多酚和阿法骨化醇对慢性炎症雌性大鼠骨骼微结构的保护作用。

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This study investigated the effects of green tea polyphenols (GTP) and alfacalcidol on bone microstructure and strength along with possible mechanisms in rats with chronic inflammation. A 12-week study using a 2 (no GTP vs. 0.5%, w/v GTP in drinking water)x2 (no alfacalcidol vs. 0.05 mug/kg alfacalcidol orally, 5x/week) factorial design was employed in lipopolysaccharide (LPS)-administered female rats. A group receiving placebo administration was used to compare with a group receiving LPS administration only to evaluate the effect of LPS. Changes in tibial and femoral microarchitecture and strength of femur were evaluated. Difference in expression of tumor necrosis factor- alpha (TNF- alpha) in proximal tibia using immunohistochemistry was examined. Compared to the placebo group, the LPS-administered-only group had significantly lower femoral mass, trabecular volume, thickness and number in proximal tibia and femur, and lower periosteal bone formation rate in tibial shafts but had significantly higher trabecular separation and osteoclast number in proximal tibia and eroded surface in endocortical tibial shafts. Both GTP and alfacalcidol reversed these LPS-induced detrimental changes in femur, proximal tibia and endocortical tibial shaft. Both GTP and alfacalcidol also significantly improved femoral strength, while significantly suppressed TNF- alpha expression in proximal tibia. There were significant interactions in femoral mass and strength, trabecular separation, osteoclast number and TNF- alpha expression in proximal tibia. A combination of both showed to sustain bone microarchitecture and strength. We conclude that a protective impact of GTP and alfacalcidol in bone microarchitecture during chronic inflammation may be due to a suppression of TNF- alpha. All rights reserved, Elsevier.
机译：这项研究调查了绿茶多酚（GTP）和阿法骨化醇对慢性炎症大鼠骨骼结构和强度的影响以及可能的机制。在脂多糖（LPS）中采用因子分解设计，使用2（无GTP对比0.5％，w / v饮用水中的GTP）x2（无阿法骨化醇vs. 0.05杯/ kg阿法骨化醇口服，5x /周）的为期12周的研究。雌性大鼠。使用接受安慰剂的组与接受LPS的组进行比较，只是为了评估LPS的效果。评估了胫骨和股骨微结构的变化以及股骨的强度。使用免疫组织化学检查了胫骨近端肿瘤坏死因子-α（TNF-α）表达的差异。与安慰剂组相比，仅LPS给药组的胫骨和股骨近端的股骨质量，小梁体积，厚度和数量明显降低，胫骨干的骨膜骨形成率较低，但在小梁分离中，小梁分离和破骨细胞数量明显增加。胫骨近端和皮层内胫骨干的侵蚀表面。 GTP和阿法骨化醇均可逆转这些LPS引起的股骨，胫骨近端和皮质内胫骨干的有害变化。 GTP和阿法骨化醇也可显着改善股骨强度，同时显着抑制胫骨近端的TNF-α表达。胫骨近端的股骨质量和强度，小梁分离，破骨细胞数量和TNF-α表达之间存在显着的相互作用。两者的结合表明可以维持骨骼的微结构和强度。我们得出结论，慢性炎症过程中GTP和阿法骨化醇对骨骼微结构的保护作用可能是由于TNF-α的抑制。保留所有权利，Elsevier。

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