首页> 外文期刊>The Journal of Nutritional Biochemistry >Serum palmitic acid-oleic acid ratio and the risk of coronary artery disease: a case-control study
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Serum palmitic acid-oleic acid ratio and the risk of coronary artery disease: a case-control study

机译:血清棕榈酸-油酸比率与冠状动脉疾病的风险:病例对照研究

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Serum free fatty acids are risk factors for future coronary artery disease (CAD). We investigated the association between serum palmitic acid (PA)-oleic acid (OA) ratio and CAD risk in a case-control (n=108/129) study. The PA-OA ratio was associated with future CAD events independently of standard lipid values. The PA-OA ratio was significantly associated with the risk of fatal CAD [odds ratio (OR): 60.4; 95% confidence interval (CI): 11.5-316.9; P<.001] while inversely associated in nonfatal CAD group (OR: 0.11; 95% CI: 0.02-0.53; P<.01), and no distinct modification by sex was found. Receiver-operating characteristic (ROC) analysis found that PA-OA ratio did as well as triglyceride (TG) and apolipoprotein B (apo B)-high-density lipoprotein cholesterol (HDLC) ratio at discriminating fatal CAD (area under ROC, TG, 0.692; apo B-HDLC, 0.683; PA-OA, 0.768, P<.001), and had similar effect with HDLC at discriminating nonfatal CADs (area under ROC, HDLC, 0.649; PA-OA, 0.659, P<.01). These findings suggested that PA-OA ratio did as well as and even better than traditional risk factors and arteriography examination in discriminating fatal and nonfatal CAD events. Serum PA-OA ratio could be a new factor for CAD risk assessment and prediction
机译:血清游离脂肪酸是未来冠心病(CAD)的危险因素。我们在病例对照研究(n = 108/129)中调查了血清棕榈酸(PA)-油酸(OA)比率与CAD风险之间的关联。 PA-OA比值与将来的CAD事件相关,而与标准脂质值无关。 PA-OA比与致命CAD的风险显着相关[比值比(OR):60.4; 95%置信区间(CI):11.5-316.9; P <.001],而在非致死性CAD组中呈负相关(OR:0.11; 95%CI:0.02-0.53; P <.01),并且未发现性别差异明显。接收者操作特征(ROC)分析发现,PA-OA比在区分致命性CAD(ROC,TG, 0.692; apo B-HDLC,0.683; PA-OA,0.768,P <.001),并且在区分非致命CAD方面与HDLC具有相似的作用(ROC下区域,HDLC,0.649; PA-OA,0.659,P <.01 )。这些发现表明,PA-OA比在区分致命性和非致命性CAD事件方面表现甚至优于传统的危险因素和动脉造影检查。血清PA-OA比可能成为CAD风险评估和预测的新因素

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