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首页> 外文期刊>The Journal of Nutritional Biochemistry >Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort.
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Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort.

机译：饱和脂肪摄入和酒精摄入可调节 APOE 多态性与未来冠心病风险之间的关联：西班牙EPIC队列中的一项嵌套病例对照研究。

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The association is still not clear between the common APOE polymorphism and coronary heart disease (CHD) risk, nor its modulation by diet. Thus, our aim was to study the association between the APOE genotypes and incident CHD and how dietary fat and alcohol consumption modify these effects. We performed a nested case-control study in the Spanish European Prospective Investigation into Cancer and Nutrition cohort. Healthy men and women (41 440, 30-69 years) were followed up over a 10-year period, with the incident CHD cases being identified. We analyzed 534 incident CHD cases and 1123 controls. APOE, dietary intake and plasma lipids were determined at baseline. The APOE polymorphism was significantly associated with low-density lipoprotein cholesterol (LDL-C), and gene-alcohol interactions in determining LDL-C were detected. In the whole population, the E2 allele was significantly associated with a lower CHD risk than E3/E3 subjects [odds ratio (OR), 0.58; 95% confidence interval (CI), 0.38-0.89]. The E4 allele did not reach statistical significance vs. E3/E3 (OR, 1.17; 95% CI, 0.88-1.58). However, saturated fat intake modified the effect of the APOE polymorphism in determining CHD risk. When saturated fat intake was low (<10% of energy), no statistically significant association between the APOE polymorphism and CHD risk was observed (P=.682). However, with higher intake (>=10%), the polymorphism was significant (P=.005), and the differences between E2 and E4 carriers were magnified (OR for E4 vs. E2, 3.33; 95% CI, 1.61-6.90). Alcohol consumption also modified the effect of the APOE on CHD risk. In conclusion, in this Mediterranean population, the E2 allele is associated with lower CHD risk, and this association is modulated by saturated fat and alcohol consumption.
机译：常见的APOE基因多态性与冠心病（CHD）风险之间的关联以及饮食调节的关联仍不清楚。因此，我们的目的是研究APOE基因型与突发性冠心病之间的联系，以及饮食中脂肪和酒精的摄入如何改变这些影响。我们在对癌症和营养人群的西班牙欧洲前瞻性调查中进行了嵌套的病例对照研究。对健康的男性和女性（41 440岁，30-69岁）进行了为期10年的随访，发现了冠心病事件。我们分析了534例冠心病事件和1123例对照。在基线时确定APOE，饮食摄入和血浆脂质。 APOE基因多态性与低密度脂蛋白胆固醇（LDL-C）显着相关，并检测到确定LDL-C的基因-酒精相互作用。在整个人群中，与E3 / E3受试者相比，E2等位基因与CHD风险显着相关[比值比（OR）为0.58; 95％置信区间（CI），0.38-0.89]。与E3 / E3相比，E4等位基因未达到统计学显着性（OR为1.17; 95％CI为0.88-1.58）。但是，饱和脂肪摄入改变了APOE多态性在确定冠心病风险中的作用。当饱和脂肪摄入量低（<能量的10％）时，未观察到APOE多态性与冠心病风险之间的统计学显着关联（P = .682）。然而，随着摄入量的增加（> = 10％），多态性显着（P = .005），并且E2和E4携带者之间的差异被放大（E4与E2的OR为3.33; 95％CI为1.61-6.90） ）。饮酒也改变了APOE对冠心病风险的影响。总之，在这个地中海人口中，E2等位基因与较低的冠心病风险有关，并且这种联系受饱和脂肪和酒精消耗的调节。

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