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首页> 外文期刊>The Journal of Nutritional Biochemistry >Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice.
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Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice.

机译：膳食异黄酮可增加胰岛素样生长因子-I的产生，从而促进小鼠毛发的生长。

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摘要

Sensory neurons release calcitonin gene-related peptide (CGRP) upon activation. We previously demonstrated that CGRP increases insulin-like growth factor-I (IGF-I) production in various tissues of mice including the skin. We demonstrated that isoflavone increases the CGRP synthesis in the dorsal root ganglion (DRG) neurons in rats. Since IGF-I plays a critical role in hair growth, we hypothesized that isoflavones may promote hair growth by increasing the IGF-I production in hair follicles. We examined this hypothesis using wild-type (WT) and CGRP-knockout (CGRP--/--) mice. Isoflavone significantly increased the CGRP mRNA levels in DRG neurons isolated from WT mice (P<.01). Administration of isoflavone for 3 weeks increased the dermal levels of CGRP, IGF-I and IGF-I mRNA in WT mice, but not in CGRP--/-- mice. Isoflavone administration increased the immunohistochemical expression of IGF-I in hair follicle dermal papilla cells in WT mice. Significant enhancements of hair follicle morphogenesis, hair regrowth, and hair pigmentation were also observed in WT mice administered isoflavone. However, none of these effects in WT mice were observed in CGRP--/-- mice. These observations strongly suggest that isoflavone might increase IGF-I production in the hair follicle dermal papilla cells in mice through increasing CGRP production in the sensory neurons, thereby promoting hair growth associated with melanogenesis in mice.
机译：感觉神经元激活后释放降钙素基因相关肽（CGRP）。先前我们证明了CGRP可在包括皮肤在内的小鼠各种组织中增加胰岛素样生长因子I（IGF-1）的产生。我们证明了异黄酮会增加大鼠背根神经节（DRG）神经元中的CGRP合成。由于IGF-I在毛发生长中起关键作用，我们假设异黄酮可能通过增加毛囊中IGF-I的产生来促进毛发生长。我们使用野生型（WT）和CGRP敲除（CGRP -/-）小鼠检验了这一假设。异黄酮显着增加了从野生型小鼠分离的DRG神经元中的CGRP mRNA水平（P <.01）。异黄酮给药3周可增加WT小鼠的CGRP，IGF-I和IGF-I mRNA的真皮水平，但不影响CGRP -/-小鼠的皮肤水平。异黄酮的施用增加了WT小鼠毛囊真皮乳头细胞中IGF-1的免疫组织化学表达。在给予异黄酮的野生型小鼠中也观察到毛囊形态发生，毛发再生和毛发色素沉着的显着增强。但是，在CGRP -/-小鼠中没有观察到这些作用于WT小鼠。这些观察结果强烈表明，异黄酮可能通过增加感觉神经元中CGRP的产生来增加小鼠毛囊真皮乳头细胞中IGF-I的产生，从而促进与黑素生成相关的毛发生长。

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