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首页> 外文期刊>The Journal of Nutritional Biochemistry >Dietary restriction preserves the mass and function of pancreatic beta cells via cell kinetic regulation and suppression of oxidative/ER stress in diabetic mice
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Dietary restriction preserves the mass and function of pancreatic beta cells via cell kinetic regulation and suppression of oxidative/ER stress in diabetic mice

机译：饮食限制可通过糖尿病小鼠的细胞动力学调节和氧化/ ER应激抑制来维持胰岛β细胞的质量和功能。

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To assess the molecular mechanisms by which dietary restriction preserves the beta-cell mass and function in diabetic db/db mice. Male db/db mice were divided into two groups with or without diet restriction. Daily food intake of db/db mice was adjusted to that of the control db/m mice, which was determined in advance. A dietary restriction was implemented for 6 weeks from 6 weeks of age. Islet morphology, beta-cell function and gene expression profiles specific for pancreatic islet cells were compared. Food intake in db/m mice was 50% of that in db/db mice. Impaired glucose tolerance and insulin sensitivity were significantly ameliorated in db/db mice with dietary restriction. The pancreatic beta-cell mass was greater in mice with dietary restriction than that in mice without intervention. The dietary restriction significantly increased cyclin D gene expression and down-regulated CAD gene expression at 12 weeks compared with untreated db/db mice. Antiapoptotic bcl-2 gene expression was significantly increased, whereas genes related to oxidative stress, ER stress and inflammatory processes, such as NADPH oxidase, CHOP10 and TNF, were markedly down-regulated in mice with dietary restriction. Dietary restriction preserved the pancreatic beta-cell function and beta-cell mass in diabetic db/db mice, suggesting that alimentary therapy prevented a-cell loss by suppressing cellular apoptosis and antioxidative stress in the pancreatic beta cells. (C) 2015 Elsevier Inc. All right reserved.
机译：评估饮食限制可保留糖尿病db / db小鼠β细胞质量和功能的分子机制。将雄性db / db小鼠分为两组，有或没有饮食限制。将db / db小鼠的每日食物摄入量调整为对照db / m小鼠的每日食物摄入量，这是事先确定的。从6周龄开始实施6周饮食限制。比较了胰岛细胞的胰岛形态，β细胞功能和基因表达谱。 db / m小鼠的食物摄入量是db / db小鼠的食物摄入量的50％。饮食限制的db / db小鼠的糖耐量和胰岛素敏感性受损明显改善。有饮食限制的小鼠的胰腺β细胞质量要比无干预的小鼠大。与未经治疗的db / db小鼠相比，饮食限制在12周时显着增加了cyclin D基因表达，并下调了CAD基因表达。抗凋亡的bcl-2基因表达显着增加，而与氧化应激，内质网应激和炎症过程相关的基因，例如NADPH氧化酶，CHOP10和TNF，在饮食限制的小鼠中明显下调。饮食限制在糖尿病db / db小鼠中保留了胰腺β细胞功能和β细胞质量，表明饮食疗法通过抑制胰腺β细胞的细胞凋亡和抗氧化应激来防止a细胞丢失。 （C）2015 Elsevier Inc.保留所有权利。

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