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首页> 外文期刊>The Journal of Nutritional Biochemistry >Intake of grape procyanidins during gestation and lactation impairs reverse cholesterol transport and increases atherogenic risk indexes in adult offspring
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Intake of grape procyanidins during gestation and lactation impairs reverse cholesterol transport and increases atherogenic risk indexes in adult offspring

机译：在妊娠和哺乳期摄入葡萄原花青素会损害胆固醇的反向运输并增加成年后代的致动脉粥样硬化风险指数

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摘要

Cardiovascular disease (CVD) is one of the most prevalent noncommunicable diseases in humans. Different studies have identified dietary procyanidins as bioactive compounds with beneficial properties against CVD by improving lipid homeostasis, among other mechanisms. The aim of this work was to assess whether grape seed procyanidin consumption at a physiological dose during the perinatal period could influence the CVD risk of the offspring. Wistar rat dams were treated with a grape seed procyanidin extract (GSPE; 25 mg/kg of body weight per day) or vehicle during gestation and lactation. The adult male offspring of GSPE-treated dams presented decreased high-density lipoprotein cholesterol (HDL-C) levels, increased total cholesterol-to-HDL-C ratios and an exacerbated fasting triglyceride-to-HDL-C ratios (atherogenic index of plasma) compared to the control group. Impaired reverse cholesterol transport (RCT) was evidenced by the accumulation of cholesterol in skeletal muscle and by decreased fecal excretion of cholesterol and bile acids, which was consistent with the observed mRNA down-regulation of the rate-limiting enzyme in the hepatic bile acid synthesis pathway Cyp7A1. Conversely, GSPE programming also resulted in up-regulated gene expression of different key components of the RCT process, such as hepatic Npc1, Abcg1, Abca1, Lxra, Srebp2, Lcat, Scarb1 and Pltp, and the repression of microRNA miR-33a expression, a key negative controller of hepatic RCT at the gene expression level. Our results show that maternal intake of grape procyanidins during the perinatal period impacts different components of the RCT process, resulting in increased CVD risk in the adult offspring. (C) 2015 Elsevier Inc. All rights reserved.
机译：心血管疾病（CVD）是人类中最普遍的非传染性疾病之一。不同的研究已将膳食原花青素鉴定为具有生物活性的化合物，其中包括通过改善脂质体内平衡来对抗CVD的有益特性。这项工作的目的是评估围产期以生理剂量食用葡萄籽原花青素是否会影响后代的CVD风险。 Wistar大鼠大坝在妊娠和哺乳期间用葡萄籽原花青素提取物（GSPE;每天25 mg / kg体重）或赋形剂处理。 GSPE处理大坝的成年雄性后代表现出高密度脂蛋白胆固醇（HDL-C）水平降低，总胆固醇与HDL-C比率增加以及空腹甘油三酸酯与HDL-C比率加剧（血浆动脉粥样硬化指数） ）与对照组相比。胆固醇在骨骼肌中的蓄积以及粪便中胆固醇和胆汁酸排泄的减少证明了胆固醇逆向转运（RCT）的降低，这与观察到的肝胆汁酸合成中限速酶的mRNA下调相一致途径Cyp7A1。相反，GSPE程序设计还导致RCT过程中不同关键成分的基因表达上调，例如肝Npc1，Abcg1，Abca1，Lxra，Srebp2，Lcat，Scarb1和Pltp，以及对microRNA miR-33a表达的抑制，在基因表达水平上，肝RCT的关键负调控因子。我们的结果表明，孕妇在围产期摄入葡萄原花青素会影响RCT过程的不同组成部分，从而导致成年后代患上CVD的风险增加。 （C）2015 Elsevier Inc.保留所有权利。

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