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首页> 外文期刊>The Journal of Nutritional Biochemistry >Supplementation with Selenium yeast on the prooxidant-antioxidant activities and anti-tumor effects in breast tumor xenograft-bearing mice
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Supplementation with Selenium yeast on the prooxidant-antioxidant activities and anti-tumor effects in breast tumor xenograft-bearing mice

机译：硒酵母对乳腺异种移植小鼠体内抗氧化和抗肿瘤活性的影响

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摘要

Selenium (Se) is essential for antioxidant activity involved in immune function and anti-carcinogenic action, whereas at higher concentrations, Se may have pro-oxidant properties. The present study was aimed at determining the effects of Se supplementation, as Se yeast, on oxidative stress in non-tumor/tumor tissues, as well as regulation of the apoptotic process, and immune responses in mice-bearing breast tumor xenografts. Female BALB/cByJNarl mice were divided into control (CNL and CNL-con), Se-supplemented control (CNL-HS, given as a single oral dose of 912 ng Se daily), breast tumor-bearing (TB and TB-con), TB-LS (228 ng Se), TB-MS (456 ng Se) and TB-HS (912 ng Se) groups. All mice were treated with/without Se for 14 days. A number of variables were further measured. Compared with the TB groups, tumor bearing mice with Se supplement had increased plasma Se concentrations, reduced erythrocyte Se-dependent glutathione peroxidase (GPx) activity and malondialdehyde (MDA) products and inhibited tumor growth. They have also higher Se concentrations in non-tumor and tumor tissues. Significantly elevated concentrations of MDA and reduced GPx activities, as well as increased anti-apoptotic bcl-2 and tumor suppressor p53 concentrations in tumor tissues were observed as Se accumulated in tumor, whereas lower MDA products were found in various non-tumor tissues than did the corresponding values. Further, there were elevated concentrations of Th1-derived cytokines and decreased Th2-type interleukin (IL)-4 in tumor-bearing mice with the treatment of Se. In conclusion, accumulation of Se in tumors may induce oxidative stress and p53-dependent pro-oxidative apoptosis, thus inhibiting the growth of breast tumor. (C) 2015 Elsevier Inc. All rights reserved.
机译：硒（Se）对于参与免疫功能和抗癌作用的抗氧化剂活性必不可少，而在较高浓度下，硒可能具有促氧化剂特性。本研究的目的是确定补充硒（如硒酵母）对非肿瘤/肿瘤组织中氧化应激的影响，以及对凋亡过程的调节以及荷瘤乳腺癌异种移植物中免疫反应的调节。将雌性BALB / cByJNarl小鼠分为对照组（CNL和CNL-con），补充硒的对照组（CNL-HS，每天口服912 ng Se单剂量），带有乳腺肿瘤的小鼠（TB和TB-con） ，TB-LS（228 ng Se），TB-MS（456 ng Se）和TB-HS（912 ng Se）组。用/不使用Se处理所有小鼠14天。进一步测量了许多变量。与结核病组相比，荷瘤小鼠补充硒的血浆浓度升高，红细胞硒依赖性谷胱甘肽过氧化物酶（GPx）活性和丙二醛（MDA）产物降低，并抑制了肿瘤的生长。它们在非肿瘤和肿瘤组织中的硒含量也较高。观察到，随着肿瘤中硒的积累，肿瘤组织中MDA的浓度显着升高，GPx活性降低，抗凋亡的bcl-2和抑癌p53浓度升高，而在各种非肿瘤组织中发现的MDA产物却降低了。相应的值。此外，在用Se处理的荷瘤小鼠中，Th1衍生的细胞因子浓度升高，Th2型白介素（IL）-4含量降低。总之，硒在肿瘤中的蓄积可能诱导氧化应激和p53依赖的前氧化细胞凋亡，从而抑制了乳腺肿瘤的生长。 （C）2015 Elsevier Inc.保留所有权利。

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