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首页> 外文期刊>Biomolecular engineering >Dextran and hyaluronan methacrylate based hydrogels as matrices for soft tissue reconstruction.
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Dextran and hyaluronan methacrylate based hydrogels as matrices for soft tissue reconstruction.

机译：葡聚糖和透明质酸甲基丙烯酸酯基水凝胶，作为软组织重建的基质。

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摘要

Polysaccharide hydrogels have become increasingly studied as matrices in soft tissue engineering because of their known cytocompatibility. In this work cross-linkable dextran methacrylates and hyaluronan methacrylate were synthesized and their transformation into stable hydrogels was studied. The in vitro degradation behaviour of the formed hydrogels could be controlled by the polysaccharide structure and the cross-linking density. Under in vitro conditions, the formed gels had no cytotoxic effects against fibroblasts, but cells could adhere only inefficiently in long term experiments. The use of composite gels improved the adherence of cells. Different scaffold architectures were studied including porous structures and perforated gel layers. Selected hydrogels were examined in an in vivo pilot study using a rabbit model to evaluate their biocompatibility, stability and degradation. No signs of inflammation were seen and with prolonged duration the material was degraded and lacunas were formed by immigrating or ingrowing cells. Optimizing their mechanical properties, the formed hydrogels represent promising candidates as matrices for soft tissue reconstruction.
机译：多糖水凝胶由于其已知的细胞相容性，已成为软组织工程中越来越多地研究的基质。在这项工作中，合成了可交联的甲基丙烯酸右旋糖酐和甲基透明质酸，并研究了它们向稳定水凝胶的转化。所形成的水凝胶的体外降解行为可以通过多糖结构和交联密度来控制。在体外条件下，形成的凝胶对成纤维细胞没有细胞毒性作用，但在长期实验中细胞只能低效地粘附。复合凝胶的使用改善了细胞的粘附。研究了不同的支架结构，包括多孔结构和多孔凝胶层。在体内实验研究中使用兔模型检查了选定的水凝胶，以评估其生物相容性，稳定性和降解性。没有看到炎症迹象，并且随着时间的延长，该物质被降解，并且由于细胞的迁移或向内生长而形成了腔隙。优化其机械性能，形成的水凝胶代表有希望的候选物，作为软组织重建的基质。

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