Selective molecular sequestration with concurrent natural product functionalization and derivatization: From crude natural product extracts to a single natural product derivative in one step

Krchňák V.; Zají?ek J.; Miller P.A.; Miller M.J.

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Selective molecular sequestration with concurrent natural product functionalization and derivatization: From crude natural product extracts to a single natural product derivative in one step

机译：选择性分子螯合，同时进行天然产物功能化和衍生化：一步一步从粗天然产物提取物到单一天然产物衍生物

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A resin-bound nitroso compound sequestered a single unexpected component from crude plant seed extracts. Several plants, including Piper nigrum, Eugenia caryophyllata, and Pimenta dioica, were extracted with organic solvent in the presence of a nitroso-containing resin. The nitroso resin selectively sequestered a single compound, β-caryophyllene, via a chemo- and regioselective ene reaction. The ene product was released from the resin, and proper selection of the solid-phase linker and cleavage cocktail allowed concomitant further transformation of the primary ene product to a novel functionalized polycycle. Preliminary studies indicate that the new hydroxylamine-containing natural product derivatives have antibiotic activity.

机译：树脂结合的亚硝基化合物从植物粗种子提取物中螯合了单个意外成分。在含亚硝基树脂的存在下，用有机溶剂提取了几种植物，包括黑胡椒，番樱桃叶番木和Pimenta dioica。亚硝基树脂通过化学和区域选择性烯反应选择性地螯合单一化合物β-石竹烯。烯产物从树脂中释放出来，适当选择固相连接物和裂解混合物可使烯产物进一步转化为新型的官能化多环。初步研究表明，新的含羟胺的天然产物衍生物具有抗生素活性。

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《The Journal of Organic Chemistry》 |2011年第24期|共5页
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Krchňák V.; Zají?ek J.; Miller P.A.; Miller M.J.;
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正文语种 eng
中图分类有机化学;
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1. Selective molecular sequestration with concurrent natural product functionalization and derivatization: From crude natural product extracts to a single natural product derivative in one step [J] . Krchňák V., Zají?ek J., Miller P.A., The Journal of Organic Chemistry . 2011,第24期

机译：选择性分子螯合，同时进行天然产物功能化和衍生化：一步一步从粗天然产物提取物到单一天然产物衍生物
2. Iminonitroso Diels-Alder Reactions for Efficient Derivatization and Functionalization of Complex Diene-Containing Natural Products [J] . Fangzheng Li, Baiyuan Yang, Marvin J. Miller, Organic letters . 2007,第15期

机译：含亚硝基的天然Diels-Alder反应有效衍生和复杂化的复杂功能。
3. Iminonitroso Diels-Alder Reactions for Efficient Derivatization and Functionalization of Complex Diene-Containing Natural Products [J] . Fangzheng Li, Baiyuan Yang, Marvin J. Miller Organic letters . 2007,第15期

机译：含亚硝基的天然Diels-Alder反应的高效衍生和功能化。
4. High Resolution IMS-MS and UHPLC-HRMS for the analysis of natural products and complex natural extracts [C] . Antonio Azzollini, Michael Groessl, Philippe J. Eugster, International Mass Spectrometry Conference . 2014

机译：高分辨率IMS-MS和UHPLC-HRMS，用于分析天然产物和复杂的自然提取物
5. Derivatives of epoxyquinoid natural products that block activation of transcription factor NF-kappaB at multiple steps. [D] . Liang, Mei-Chih. 2006

机译：环氧醌类天然产物的衍生物可在多个步骤中阻止转录因子NF-κB的活化。
6. Selective Molecular Sequestration with Concurrent Natural Product Functionalization and Derivatization: From Crude Natural Product Extracts to a Single Natural Product Derivative in One Step [O] . Viktor Krchňák, Jaroslav Zajíček, Patricia A. Miller, -1

机译：选择性分子封存并发天然产物功能化和衍生化：从原油中天然提取物以单一天然产品衍生物一步
7. Selective Molecular Sequestration with Concurrent Natural Product Functionalization and Derivatization: From Crude Natural Product Extracts to a Single Natural Product Derivative in One Step [O] . Viktor Krchňák, Jaroslav Zajíček, Patricia A. Miller, 2011

机译：用同时的天然产品官能化和衍生化选择性分子封存：从粗天然产物提取到单一的天然产物衍生物一步

Selective molecular sequestration with concurrent natural product functionalization and derivatization: From crude natural product extracts to a single natural product derivative in one step

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