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首页> 外文期刊>The journal of sexual medicine >Morphological and functional evidence for the contribution of the pudendal artery in aging-induced erectile dysfunction.
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Morphological and functional evidence for the contribution of the pudendal artery in aging-induced erectile dysfunction.

机译：阴部动脉在衰老引起的勃起功能障碍中的作用的形态学和功能证据。

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INTRODUCTION: Aging increases the risk of both erectile dysfunction (ED) and cardiovascular disease. These conditions have similar etiologies and commonly coexist. One unifying concept is the role of arterial insufficiency which is a primary factor in the onset of age-related ED. AIM: Based on the novel finding that the pudendal arteries contribute 70% of the total penile vascular resistance, our objective was to morphometrically and functionally characterize this vessel in young and old normotensive rats. METHODS: Erectile function was monitored in 15- and 77-week Sprague-Dawley rats using the apomorphine bioassay (80mg/kg, s.c.). Anesthetized animals were perfusion-fixed, aortic, renal, and internal pudendal arteries were excised, embedded, sectioned, stained, and morphometrically assessed using light microscopy. Hearts were excised, separated, and weighed prior to perfusion. Contractile and relaxation responses to acetylcholine (ACh) and phenylephrine (PE) were assessed by wire myograph. MAIN OUTCOME MEASURES: Erectile function, morphological measurements, concentration response curves to ACh and PE. RESULTS: With age, there were marked decreases in erectile responses compared to younger rats (2.8+/-0.87 vs. 0.3+/-0.58). The pudendal arteries had a relatively small lumen (303+/-13.8microm) and a thick medial layer (47+/-2.2microm). In aged pudendal arteries, the lumen diameter did not change, and yet the medial layer, cross sectional area, and extracellular matrix were markedly increased. In contrast, the lumen diameter and wall thickness of the aorta and renal arteries in aged rats increased proportionally. An increase in small, round, smooth muscle cells was seen in aged pudendal arteries. Functionally, there were no differences in contractile responses to PE; however, ACh-induced relaxation decreased with age. CONCLUSIONS: In aged rats, erectile function was severely diminished when pudendal arteries had undergone marked phenotypic changes. Specifically, there was endothelial dysfunction and pathological remodeling of this vessel with age, characterized by medial thickening, impaired vasodilation and significantly reduced capacity for penile blood flow.
机译：简介：衰老会增加勃起功能障碍（ED）和心血管疾病的风险。这些病因具有相似的病因并且通常共存。一个统一的概念是动脉供血不足的作用，这是与年龄有关的ED发作的主要因素。目的：基于新发现，阴部动脉占总阴茎血管阻力的70％，我们的目标是在年轻和老年血压正常的大鼠中从形态学和功能上表征该血管。方法：采用阿扑吗啡生物测定法（80mg / kg，皮下注射）监测15周和77周Sprague-Dawley大鼠的勃起功能。对麻醉的动物进行灌流固定，将主动脉，肾和阴部内动脉切除，包埋，切片，染色并使用光学显微镜对其形态进行评估。在灌注之前，将心脏切除，分离并称重。通过钢丝肌电图仪评估对乙酰胆碱（ACh）和去氧肾上腺素（PE）的收缩和松弛反应。主要观察指标：勃起功能，形态学测量，对ACh和PE的浓度反应曲线。结果：与年龄相比，与年轻大鼠相比，勃起反应明显降低（2.8 +/- 0.87对0.3 +/- 0.58）。阴部动脉具有相对较小的内腔（303 +/-13.8μm）和较厚的内侧层（47 +/-2.2μm）。在老年阴部动脉中，管腔直径没有变化，但内侧层，横截面积和细胞外基质明显增加。相反，老年大鼠的内腔直径和主动脉及肾动脉的壁厚成比例地增加。在老年阴部动脉中可见小而圆形的平滑肌细胞增加。在功能上，对PE的收缩反应没有差异。然而，乙酰胆碱引起的放松随年龄增长而降低。结论：在老年大鼠中，当阴部动脉发生明显的表型改变时，勃起功能严重减弱。具体而言，随着年龄的增长，该血管存在内皮功能障碍和病理重塑，其特征是内侧增厚，血管舒张受损和阴茎血流能力明显降低。

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