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首页> 外文期刊>The journal of sexual medicine >Metrics for evaluation of age-related changes in erectile capacity in a rodent model.
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Metrics for evaluation of age-related changes in erectile capacity in a rodent model.

机译：在啮齿动物模型中评估与年龄相关的勃起能力变化的指标。

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INTRODUCTION: Stimulation of the cavernous nerve elicits increases in intracavernosal pressure (ICP) and visible penile erection (VPE) in rats. The observed penile erection can be characterized by the change in ICP and the ratio of ICP over blood pressure (BP; systemic blood pressure). AIM: We evaluated correlations between ICP, BP, ICP/BP, and VPE, and the magnitude of the nerve stimulation required to elicit those responses in order to evaluate age-related changes in erectile function in a rodent model. METHODS: Nine young (3 months) and 10 old (18 months) rats were used. Under anesthesia cavernous nerve stimulation was performed at stimulation strengths ranging from 0.1 to 10 mA. MAIN OUTCOME MEASURES: The ICP, BP, ICP/BP, and VPE responses to cavernous nerve stimulation were quantified and compared. RESULTS: Significant correlations were observed between ICP and ICP/BP in both young (r(2) = 0.886) and old (r(2) = 0.962) rats. If the ratio ICP/BP was taken as a metric of VPE and non-erection, then the threshold value for observing a VPE in the majority of animals was > or =0.5 in both young and old rats. However, higher current stimulation was required in the old than in the young animals to achieve erections. Moreover, both the maximal ICP and ICP/BP ratios achieved during erection were also lower in the old (85 +/- 2 cmH(2)O and 0.6 +/- 0.02, respectively) than young (106 +/- 3 cmH(2)O and 0.75 +/- 0.02, respectively) rats (P < 0.0001). CONCLUSION: Old rats without obvious comorbidities were capable of penile erections, but those erections were accompanied by reduced ICP responses to cavernous nerve stimulation, implying apparently reduced penile rigidity. Taken together our current observations indicate that ICP, ICP/BP, and VPE provide useful metrics/indices of erectile capacity/function, and, moreover, that improved understanding of the inter-relationships among these parameters provides a frame work for further exploration of the mechanistic basis for age-related erectile dysfunction.
机译：引言：刺激大鼠海绵体神经引起海绵体内压（ICP）和可见阴茎勃起（VPE）。观察到的阴茎勃起可以通过ICP的变化以及ICP与血压的比率（BP;全身性血压）来表征。目的：我们评估了ICP，BP，ICP / BP和VPE之间的相关性，以及诱发这些反应所需的神经刺激的强度，以评估啮齿动物模型中与年龄相关的勃起功能的变化。方法：使用9只年轻（3个月）和10只大（18个月）大鼠。在麻醉下，以0.1至10mA的刺激强度进行海绵状神经刺激。主要观察指标：量化并比较ICP，BP，ICP / BP和VPE对海绵状神经刺激的反应。结果：在幼鼠（r（2）= 0.886）和老年（r（2）= 0.962）大鼠中，ICP和ICP / BP之间存在显着相关性。如果将ICP / BP比作为VPE和不勃起的度量标准，则在大多数动物中观察到的VPE的阈值在年轻和成年大鼠中均大于或等于0.5。但是，要达到勃起，与年幼的动物相比，年长的动物需要更高的电流刺激。此外，在老年期间（分别为85 +/- 2 cmH（2）O和0.6 +/- 0.02），在年轻人中（106 +/- 3 cmH（ 2）O和0.75 +/- 0.02分别为大鼠（P <0.0001）。结论：没有明显合并症的老年大鼠能够进行阴茎勃起，但是这些勃起伴随着对海绵状神经刺激的ICP反应降低，这表明阴茎的硬度明显降低。综上所述，我们目前的观察结果表明，ICP，ICP / BP和VPE提供了勃起功能/功能的有用指标/指标，而且，对这些参数之间相互关系的更好理解为进一步探索这些参数提供了框架。与年龄有关的勃起功能障碍的机制基础。

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