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Zonisamide-related erectile dysfunction.

机译：唑尼沙胺相关的勃起功能障碍。

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摘要

We read with interest the article by Maschio et al. [1] on a patient affected by brain tumor-related epilepsy with reversible erectile dysfunction (ED) due to Zonisamide (ZNS). Old liver enzyme-inducing antiepileptic drugs (AEDs), such as carbamazepine, phenytoin, and phenobarbital, are known to commonly provoke sexual dysfunctions by decreasing bioactive testosterone, accelerating sexual hormone metabolism and stimulating binding hormone production. On the contrary, only a few anecdotal reports have described new AEDs-related ED [2,3], although pathogenetic mechanisms remain unclear. We reported on a patient with topira-mate (TPM)-induced ED, in which sexual hormones were within normal range, as well as psychological, neurophysiological, and ultrasound tests [3].
机译：我们感兴趣地阅读了Maschio等人的文章。 [1]患有因唑尼沙胺（ZNS）引起的可逆性勃起功能障碍（ED）的脑肿瘤相关性癫痫患者。已知诸如卡马西平，苯妥英钠和苯巴比妥之类的旧的诱导肝酶的抗癫痫药（AED）通常通过减少生物活性睾丸激素，加速性激素代谢和刺激结合激素的产生而引起性功能障碍。相反，尽管发病机理尚不清楚，但只有少数传闻报道描述了新的与AEDs相关的ED [2,3]。我们报道了一名接受托吡酯（TPM）诱导的ED的患者，其中性激素在正常范围内，并且进行了心理，神经生理学和超声检查[3]。

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