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首页> 外文期刊>The Journal of Thoracic and Cardiovascular Surgery >Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure model
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Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure model

机译：在慢性心力衰竭模型中，通过具有自然心脏负荷控制系统的连续流量左心室辅助设备改变左心室负荷

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Objective We previously developed a native heart load control system for a continuous-flow left ventricular assist device and demonstrated that the rotational speed synchronized with the cardiac cycle can alter left ventricular preload and myocardial oxygen consumption. In the present study, we assessed this system in a conscious goat model of chronic heart failure. Methods Chronic heart failure was induced by coronary microsphere embolization of the left ascending artery and subsequent rapid ventricular pacing in 6 goats. After 4 to 6 weeks of rapid pacing, the goats showed a decreased ejection fraction (from 89.7% ± 3.1% to 53.3% ± 5.4%) measured during sinus rhythm. The assist device was implanted by way of a left thoracotomy, and we examined the effects of the continuous, co-pulse, and counterpulse mode on the end-diastolic volume and stroke work, determined from the left ventricular pressure-volume loops. Results Significant decreases were found in the end-diastolic volume and stroke work in the counterpulse mode relative to the values observed with 0% bypass (63.4% ± 15.2% and 39.1% ± 18.2%, respectively; P <.01). Furthermore, both increased in the co-pulse mode (82.1% ± 17.6% and 68.3% ± 22.2%; P <.01) compared with those in the continuous mode (69.6% ± 15.4% and 54.6% ± 21.6%) with 100% bypass. Conclusions The system offers the possibility to control the left ventricular load by changing the rotational speed of a continuous-flow assist device in synchronization with the cardiac cycle. This system should provide the most favorable left ventricular loading conditions for recovery of the native heart.
机译：目的我们以前为连续流左心室辅助设备开发了一种本机心脏负荷控制系统，并证明与心动周期同步的转速可以改变左心室预负荷和心肌耗氧量。在本研究中，我们在有意识的慢性心力衰竭山羊模型中评估了该系统。方法六只山羊的冠状动脉微球栓塞和随后的快速心室起搏诱发了慢性心力衰竭。快速起搏4至6周后，在窦性心律期间测得的山羊射血分数降低了（从89.7％±3.1％降低到53.3％±5.4％）。该辅助装置是通过左胸廓切开术植入的，我们检查了连续，同搏和反搏方式对舒张末期容积和中风功的影响，这由左心室压力容积环确定。结果相对于0％旁通时观察到的值，在反脉冲模式下舒张末期容积和冲程功显着降低（分别为63.4％±15.2％和39.1％±18.2％; P <.01）。此外，与连续模式（69.6％±15.4％和54.6％±21.6％）相比，同脉冲模式下两者均增加（82.1％±17.6％和68.3％±22.2％; P <.01）。 ％ 旁路。结论该系统提供了通过与心脏周期同步地改变连续流辅助装置的旋转速度来控制左心室负荷的可能性。该系统应提供最有利的左心室负荷条件，以恢复天然心脏。

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