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首页> 外文期刊>The Journal of toxicological sciences >Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress.
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Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress.

机译：纳摩尔浓度的三氯卡班会增加大鼠胸腺细胞对氧化应激的脆弱性。

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摘要

It was recently reported that triclocarban was absorbed significantly from soap used during showering in human subjects and that its C(max) in their whole blood ranged from 23 nM to 530 nM. We revealed that a nanomolar concentration (300 nM) of triclocarban potentiated the cytotoxicity of 300 μM H(2)O(2) in rat thymocytes by using cytometric techniques with appropriate fluorescent probes. Although 300 nM triclocarban did not itself increase the population of dead cells (cell lethality), it facilitated the process of cell death induced by H(2)O(2), resulting in a further increase in the population of dead cells. Nanomolar concentrations (300 nM or higher) of triclocarban significantly decreased the cellular content of nonprotein thiol (glutathione), which has a protective role against oxidative stress. Triclocarban at 300 nM or higher increased the cell vulnerability to oxidative stress. The results may suggest that nanomolar concentration (300 nM or higher) of triclocarban affects some cellular functions although there is no evidence for adverse effects of triclocarban in humans at present.
机译：最近有报道说，三氯卡班在淋浴过程中被人类受试者的肥皂吸收很多，其全血C（max）范围为23 nM至530 nM。我们揭示了纳摩尔浓度（300 nM）的三氯卡班可通过使用适当的荧光探针进行细胞计数技术来增强大鼠胸腺细胞中300μMH（2）O（2）的细胞毒性。虽然300 nM三氯卡班本身并没有增加死细胞的数量（细胞致死率），但它促进了H（2）O（2）诱导的细胞死亡过程，导致死细胞的数量进一步增加。三氯卡班的纳摩尔浓度（300 nM或更高）显着降低了非蛋白质硫醇（谷胱甘肽）的细胞含量，对氧化应激具有保护作用。 300 nM或更高的三氯卡班会增加细胞对氧化应激的脆弱性。结果表明，三氯卡班的纳摩尔浓度（300 nM或更高）会影响某些细胞功能，尽管目前尚无证据表明三氯卡班会对人体产生不良影响。

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