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Diet in infancy and later signs of beta-cell autoimmunity.

机译:婴儿期饮食和β细胞自身免疫的后期体征。

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摘要

Knip et al. report that the use of hydrolyzed formula reduced the incidence of beta-cell-specific autoantibodies in children with genetic susceptibility. However, autoantibodies can be present transiently and may not increase the risk of type 1 diabetes. Yu et al. found that 1.7% of first-degree relatives of persons with type 1 diabetes had transient autoantibodies and all of them had only one autoantibody. Kukko et al. found that 13.8% of children with moderate-to-high risk HLA alleles for type 1 diabetes were positive for one or more autoantibodies at least once, but only 9.0% remained positive on consecutive samples. Nobody with one autoantibody had progression to type 1 diabetes in both studies.
机译:Knip等。报告指出,使用水解配方奶粉可降低具有遗传易感性的儿童中β细胞特异性自身抗体的发生率。但是,自身抗体可以短暂存在,可能不会增加1型糖尿病的风险。 Yu等。发现1型糖尿病患者一级亲属中有1.7%患有短暂性自身抗体,而所有人都只有一种自身抗体。 Kukko等。研究发现,有13.8%的1型糖尿病中至高风险HLA等位基因儿童至少一种或多种自身抗体呈阳性,但在连续样本中只有9.0%呈阳性。两项研究均未发现具有一种自身抗体的人发展为1型糖尿病。

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