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首页> 外文期刊>The New England journal of medicine >Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease.
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Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease.

机译：非甾体类抗炎药和阿尔茨海默氏病的风险。

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BACKGROUND: Previous studies have suggested that the use of nonsteroidal antiinflammatory drugs (NSAIDs) may help to prevent Alzheimer's disease. The results, however, are inconsistent. METHODS: We studied the association between the use of NSAIDs and Alzheimer's disease and vascular dementia in a prospective, population-based cohort study of 6989 subjects 55 years of age or older who were free of dementia at base line, in 1991. To detect new cases of dementia, follow-up screening was performed in 1993 and 1994 and again in 1997 through 1999. The risk of Alzheimer's disease was estimated in relation to the use of NSAIDs as documented in pharmacy records. We defined four mutually exclusive categories of use: nonuse, short-term use (1 month or less of cumulative use), intermediate-term use (more than 1 but less than 24 months of cumulative use), and long-term use (24 months or more of cumulative use). Adjustments were made by Cox regression analysis for age, sex, education, smoking status, and the use or nonuse of salicylates, histamine Hz-receptor antagonists, antihypertensive agents, and hypoglycemic agents. RESULTS: During an average follow-up period of 6.8 years, dementia developed in 394 subjects, of whom 293 had Alzheimer's disease, 56 vascular dementia, and 45 other types of dementia. The relative risk of Alzheimer's disease was 0.95 (95 percent confidence interval, 0.70 to 1.29) in subjects with short-term use of NSAIDs, 0.83 (95 percent confidence interval, 0.62 to 1.11) in those with intermediate-term use, and 0.20 (95 percent confidence interval, 0.05 to 0.83) in those with long-term use. The risk did not vary according to age. The use of NSAIDs was not associated with a reduction in the risk of vascular dementia. CONCLUSIONS: The long-term use of NSAIDs may protect against Alzheimer's disease but not against vascular dementia.
机译：背景：先前的研究表明，使用非甾体类抗炎药（NSAID）可能有助于预防阿尔茨海默氏病。但是结果不一致。方法：我们于1991年在一项基于人群的前瞻性队列研究中研究了NSAIDs的使用与阿尔茨海默氏病和血管性痴呆之间的关联性，该研究于1991年对基线时无痴呆症的6989名55岁或以上的受试者进行了研究。对于痴呆的病例，在1993年和1994年进行了随访筛查，并在1997年至1999年再次进行了筛查。如药房记录中所述，与使用非甾体抗炎药有关，估计了阿尔茨海默氏病的风险。我们定义了四种互斥的使用类别：不使用，短期使用（累计使用1个月或更短时间），中期使用（累计使用超过1个月但少于24个月）和长期使用（24累计使用数月或更长时间）。通过Cox回归分析对年龄，性别，教育程度，吸烟状况以及是否使用水杨酸盐，组胺Hz受体拮抗剂，降压药和降糖药进行了调整。结果：在平均6.8年的随访期内，共有394名受试者患了痴呆，其中293名患有阿尔茨海默氏病，56名血管性痴呆和45种其他类型的痴呆。短期使用NSAID的受试者的阿尔茨海默氏病相对风险为0.95（95％的置信区间，0.70至1.29），中期使用NSAID的受试者为0.83（95％的置信区间，0.62至1.11），而0.20（长期使用者的置信区间为95％，0.05至0.83）。风险没有因年龄而异。使用NSAID与降低血管性痴呆的风险无关。结论：长期使用非甾体抗炎药可以预防阿尔茨海默氏病，但不能预防血管性痴呆。

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