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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus.
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Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus.

机译：衰老减少了缺氧诱导的啮齿类动物海马微血管的生长。

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The effect of aging on microvascular density and plasticity in the rodent hippocampus, a brain region critically important for learning and memory, was investigated in F344xBN rats. Capillary density and angiogenesis were measured in three regions of the hippocampus in young and old rats and in old rats administered growth hormone, a treatment that improves cognitive function in older animals. Animals were housed under control conditions or in hypoxic conditions (11% ambient oxygen levels) to stimulate vascular growth. Our results indicate that aging is not associated with a reduction in hippocampal capillary density. However, aged animals demonstrate a significant impairment in hypoxia-induced capillary angiogenesis compared to young animals. Growth hormone treatment to aged animals for 6 weeks did not alter hippocampal capillary density and did not ameliorate the age-related deficit in angiogenesis. We conclude that aging significantly reduces hippocampal microvascular plasticity, which is not improved with growth hormone therapy.
机译：在F344xBN大鼠中研究了衰老对啮齿类动物海马微血管密度和可塑性的影响，海马是学习和记忆的关键区域。在幼年和老年大鼠以及给予生长激素的老年大鼠的海马三个区域中，测量了毛细血管密度和血管生成，这种治疗可改善老年动物的认知功能。将动物饲养在对照条件下或缺氧条件下（环境氧含量为11％）以刺激血管生长。我们的结果表明衰老与海马毛细血管密度的降低无关。然而，与年幼动物相比，老年动物在低氧诱导的毛细血管新生中表现出明显的损伤。对成年动物进行6周生长激素治疗不会改变海马毛细血管密度，也不会改善与年龄有关的血管生成缺陷。我们得出的结论是，衰老会明显降低海马微血管可塑性，而生长激素治疗并不能改善衰老。

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