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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Serum creatinine and functional limitation in elderly persons.
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Serum creatinine and functional limitation in elderly persons.

机译：老年人的血清肌酐和功能限制。

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BACKGROUND: Creatinine is a commonly used measure of kidney function, but serum levels are also influenced by muscle mass. We hypothesized that higher serum creatinine would be associated with self-reported functional limitation in community-dwelling elderly. METHODS: Subjects (n = 1,553) were participants in the Study of Physical Performance and Age-Related Changes in Sonomans, a cohort to study aging and physical function. We explored three strategies to account for the effects of muscle mass on serum creatinine. RESULTS: We observed a J-shaped association of creatinine with functional limitation. Above the study-specific mean creatinine (0.97 mg/dL in women and 1.15 mg/dL in men), the unadjusted odds ratio of functional limitation per standard deviation (0.20 mg/dL in women and 0.23 mg/dL in men) higher creatinine was 2.27 (95% confidence interval [CI] 1.75-2.94, p < .001) in women and 1.42 (95% CI 1.12-1.80, p = .003) in men. This association was inverted in persons with creatinine levels below the mean. Adjustment for muscle mass did not have an important effect on the association between creatinine and functional limitation. These associations remained after multivariable adjustment for demographics and health conditions but were statistically significant only in women. CONCLUSIONS: In elderly adults, higher creatinine levels are associated with functional limitation, consistent with prior literature that has demonstrated reduced physical performance in persons with kidney disease. However, the association of low creatinine levels with functional limitation suggests that creatinine levels are influenced by factors other than kidney function and muscle mass in the elderly.
机译：背景：肌酐是肾脏功能的常用指标，但血清水平也受肌肉质量的影响。我们假设较高的血清肌酐将与社区居民中自我报告的功能受限有关。方法：对象（n = 1,553）是参加Sonomans身体机能和年龄相关变化研究的参与者，该队列研究了衰老和身体机能。我们探索了三种策略来说明肌肉质量对血清肌酐的影响。结果：我们观察到肌酐的J型关联与功能限制。高于研究特定的平均肌酐水平（女性为0.97 mg / dL，男性为1.15 mg / dL），每个标准差的功能限制未校正比值比（女性为0.20 mg / dL，男性为0.23 mg / dL）更高女性为2.27（95％置信区间[CI] 1.75-2.94，p <.001），男性为1.42（95％CI 1.12-1.80，p = .003）。在肌酐水平低于平均值的人中，这种关联是相反的。肌肉质量的调整对肌酐和功能限制之间的关联没有重要影响。在对人口和健康状况进行多变量调整后，这些关联仍然存在，但仅在女性中具有统计学意义。结论：在老年人中，较高的肌酐水平与功能受限有关，这与先前的文献已经证明肾病患者的身体机能下降有关。然而，肌酐水平低与功能限制的联系提示，肌酸水平受老年人肾脏功能和肌肉质量以外的因素影响。

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