• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Use of growth hormone for prevention or treatment of effects of aging.
【24h】

Use of growth hormone for prevention or treatment of effects of aging.

机译：使用生长激素预防或治疗衰老的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Decreases in growth hormone (GH) and insulin-like growth factor-I, estrogen deficiency in women, diminished testosterone in men, and loss of lean body mass, increased fat, and other changes consistent with hormone deficiencies occur during aging. Treatment of nonelderly GH-deficient adults with recombinant human GH (rhGH) improves body composition, muscle strength, physical function, and bone density, and reduces blood cholesterol and cardiovascular disease risk, but is often accompanied by carpal tunnel syndrome, peripheral edema, joint pain and swelling, gynecomastia, glucose intolerance, and possibly increased cancer risk. Reports that rhGH augments lean body mass and reduces body fat in aged individuals increased use of rhGH to delay aging effects. However, clinically significant functional benefits, prolongation of youth, and life extension have not been demonstrated. Moreover, marketing of rhGH and other hormone supplements largely ignores adverse effects. Until more research has better defined the risk/benefit relationships, treatment of elderly individuals with rhGH should be confined to controlled research studies.
机译：生长激素（GH）和胰岛素样生长因子I降低，女性雌激素缺乏，男性睾丸激素减少，瘦体重减少，脂肪增加以及其他与衰老过程中激素缺乏相符的变化。用重组人GH（rhGH）治疗非老年人GH缺乏的成年人可改善身体组成，肌肉力量，身体机能和骨密度，降低血液胆固醇和心血管疾病的风险，但通常伴有腕管综合症，外周水肿，关节疼痛和肿胀，女性乳房发育，葡萄糖耐受不良，并可能增加患癌症的风险。有报道说，rhGH可增加老年人的瘦体重并减少体内脂肪，增加了rhGH的使用以延缓衰老的影响。但是，尚未证明具有临床意义的功能性益处，延长青春期和延长寿命。此外，rhGH和其他激素补充剂的销售在很大程度上忽略了不利影响。在更多的研究更好地定义风险/获益关系之前，rhGH的老年患者的治疗应仅限于对照研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号