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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >The effects of aging and genotype on NMDA receptor expression in growth hormone receptor knockout (GHRKO) mice.
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The effects of aging and genotype on NMDA receptor expression in growth hormone receptor knockout (GHRKO) mice.

机译：衰老和基因型对生长激素受体敲除（GHRKO）小鼠中NMDA受体表达的影响。

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摘要

Caloric restriction enhances N-methyl-D-aspartate (NMDA) receptor binding and upregulates messenger RNA expression of the GluN1 subunit during aging. Old growth hormone receptor knockout mice resemble old calorically restricted rodents in enhanced life span and brain function, as compared with aged controls. This study examined whether aged growth hormone receptor knockout mice also show enhanced expression of NMDA receptors. Six or 23- to 24-month-old male normal-sized control or dwarf growth hormone receptor knockout mice were assayed for NMDA-displaceable [(3)H]glutamate binding (autoradiography) and GluN1 subunit messenger RNA (in situ hybridization). There was slight sparing of NMDA receptor binding densities within aged medial prefrontal and motor cortices, similar to caloric restriction, but there were greater age-related declines in GluN1 messenger RNA in growth hormone receptor knockout versus control mice. These results suggest that some of the functional improvements in aged mice with altered growth hormone signaling may be due to enhancement of NMDA receptors, but not through the upregulation of messenger RNA for the GluN1 subunit.
机译：热量限制会增强N-甲基-D-天冬氨酸（NMDA）受体的结合，并在衰老过程中上调GluN1亚基的信使RNA表达。与年龄较大的对照组相比，衰老的生长激素受体敲除小鼠在寿命和脑功能方面类似于受热量限制的啮齿动物。这项研究检查了衰老的生长激素受体敲除小鼠是否还显示出NMDA受体的表达增强。分析了六只或23至24个月大的正常大小的雄性对照或矮小生长激素受体敲除小鼠的NMDA置换型[（3）H]谷氨酸结合（放射自显影）和GluN1亚基信使RNA（原位杂交）。与热量限制相似，老年内侧前额叶和运动皮层中的NMDA受体结合密度略有保留，与热量限制类似，但生长激素受体敲除后的GluN1信使RNA的衰老与对照组相比更大。这些结果表明，具有变化的生长激素信号的衰老小鼠的某些功能改善可能是由于NMDA受体的增强，而不是由于GluN1亚基的信使RNA上调所致。

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