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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling women.
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Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling women.

机译：老年残疾社区居民妇女的血清25-羟基维生素D和肺功能。

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Recent studies have expanded the functions of vitamin D to a possible role in pulmonary function. Our objective was to examine the relationship between serum 25-hydroxyvitamin D (25[OH]D), serum parathyroid hormone, and pulmonary function in older women.We examined the relationship of serum 25(OH)D and parathyroid hormone with pulmonary function (forced expiratory volume in one second [FEV(1)], forced vital capacity [FVC], and FEV(1)/FVC ratio) in a cross-sectional study of 646 moderately to severely disabled women, 65 years or more, living in the community in Baltimore, Maryland, who participated in the Women's Health and Aging Study I.Overall, median (25th, 75th percentile) serum 25-hydroxyvitamin D concentrations were 19.9 (14.7, 26.7) ng/mL. Serum 25(OH)D was positively associated with FEV(1) (p = .03), FVC (p = .18), and FEV(1)/FVC (p = .04) in multivariable linear regression models adjusting for age, race, education, smoking, height, physical activity, cognition, interleukin-6, chronic diseases, and other potential confounders. In the same models, serum parathyroid hormone was not significantly associated with FEV(1), FVC, or FEV(1)/FVC.These findings support the idea that vitamin D deficiency is independently associated with poor pulmonary function in older disabled women.
机译：最近的研究已将维生素D的功能扩展到可能在肺功能中发挥作用。我们的目的是检查老年妇女血清25-羟基维生素D（25 [OH] D），甲状旁腺激素与肺功能的关系。我们研究了血清25（OH）D和甲状旁腺激素与肺功能的关系（在646位年龄在65岁以上的中度至重度残疾妇女中进行的横断面研究中，在一秒钟内的强制呼气量[FEV（1）]，强制肺活量[FVC]和FEV（1）/ FVC比值）马里兰州巴尔的摩市的社区参加了妇女健康与衰老研究I.总体而言，血清25-羟基维生素D的中位数（第25、75个百分位数）为19.9（14.7，26.7）ng / mL。在针对年龄进行调整的多变量线性回归模型中，血清25（OH）D与FEV（1）（p = .03），FVC（p = .18）和FEV（1）/ FVC（p = .04）正相关。 ，种族，教育，吸烟，身高，体育活动，认知，白介素6，慢性疾病和其他潜在的混杂因素。在同一模型中，血清甲状旁腺激素与FEV（1），FVC或FEV（1）/ FVC没有显着相关性。这些发现支持这样的观点，即维生素D缺乏与老年残疾妇女的肺功能差独立相关。

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