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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Aging, the central nervous system, and mobility
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Aging, the central nervous system, and mobility

机译：衰老，中枢神经系统和活动能力

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Background. Mobility limitations are common and hazardous in community-dwelling older adults but are largely understudied, particularly regarding the role of the central nervous system (CNS). This has limited development of clearly defined pathophysiology, clinical terminology, and effective treatments. Understanding how changes in the CNS contribute to mobility limitations has the potential to inform future intervention studies. Methods. A conference series was launched at the 2012 conference of the Gerontological Society of America in collaboration with the National Institute on Aging and the University of Pittsburgh. The overarching goal of the conference series is to facilitate the translation of research results into interventions that improve mobility for older adults. Results. Evidence from basic, clinical, and epidemiological studies supports the CNS as an important contributor to mobility limitations in older adults without overt neurologic disease. Three main goals for future work that emerged were as follows: (a) develop models of mobility limitations in older adults that differentiate aging from disease-related processes and that fully integrate CNS with musculoskeletal contributors; (b) quantify the contribution of the CNS to mobility loss in older adults in the absence of overt neurologic diseases; (c) promote cross-disciplinary collaboration to generate new ideas and address current methodological issues and barriers, including real-world mobility measures and life-course approaches. Conclusions. In addition to greater cross-disciplinary research, there is a need for new approaches to training clinicians and investigators, which integrate concepts and methodologies from individual disciplines, focus on emerging methodologies, and prepare investigators to assess complex, multisystem associations.
机译：背景。在社区居住的老年人中，行动不便是常见且危险的，但在很大程度上没有得到充分研究，特别是在中枢神经系统（CNS）的作用方面。这限制了明确定义的病理生理学，临床术语和有效疗法的发展。了解中枢神经系统的变化如何导致行动不便，有可能为将来的干预研究提供参考。方法。与美国国家老龄研究所和匹兹堡大学合作，在美国老年医学学会2012年会议上启动了一系列会议。会议系列的总体目标是促进将研究结果转化为可改善老年人流动性的干预措施。结果。来自基础，临床和流行病学研究的证据支持中枢神经系统是导致没有明显神经系统疾病的老年人行动受限的重要因素。出现的未来工作的三个主要目标如下：（a）建立老年人活动受限的模型，以区分衰老与疾病相关过程，并将中枢神经系统与肌肉骨骼贡献者完全融合; （b）在没有明显的神经系统疾病的情况下，量化中枢神经系统对老年人运动能力丧失的贡献; （c）促进跨学科合作，以产生新的想法并解决当前的方法论问题和障碍，包括现实世界中的流动性措施和人生历程方法。结论。除了更多的跨学科研究之外，还需要培训临床医生和研究人员的新方法，这些方法应整合来自各个学科的概念和方法，专注于新兴方法，并为研究人员准备评估复杂的多系统关联。

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